Genetic, cellular, and molecular analyses reveal that the reduced abundance of total nascent transcripts that occurs after irradiation is largely due to the repression of histone and rRNA encoding genes.
The immune microenvironment has a pivotal role in hepatocellular carcinoma (HCC) progression and immune therapy resistance, and targeting this complex milieu holds great promise for improving therapeutic outcomes and patient prognoses in HCC management.
Alex Weiss, Cassandra D'Amata ... Madeline N Hayes
Modeling glioblastoma using expression of relevant human oncogenes in syngeneic zebrafish offers a powerful platform for current and future biological discovery, diagnostics, and therapeutic testing in an intact tumor microenvironment.
The phosphorylation of FLS2 may activate flg22-triggered immunity by facilitating the partitioning of FLS2 into functional AtRem1.3-associated nanodomains.
Harshvardhan Gazula, Henry FJ Tregidgo ... Juan E Iglesias
New open-source software enables, for the first time, extraction of quantitative information from brain dissection photographs that are routinely taken at brain banks for archiving purposes but otherwise not exploited.
Modification of pectin, a component of the plant cell wall, is required to facilitate signaling by a RALF peptide, which is essential for many physiological and developmental processes.
Gregory Caleb Howard, Jing Wang ... William P Tansey
Analysis of the action of WDR5 inhibitors in leukemia cells reveals decreased ribosome inventory, impaired protein synthesis, induction of nucleolar stress, and activation of p53 via alternative splicing of MDM4.
Subtelomeric sequences in the yeast S. cerevisiae are dispensable for either cell proliferation or homologous recombination-mediated telomere maintenance in telomerase-null cells, suggesting that these sequences represent remnants of genome evolution.
