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    1. Evolutionary Biology

    Palatal morphology predicts the paleobiology of early salamanders

    Jia Jia, Guangzhao Li, Ke-Qin Gao
    Salamanders originate as metamorphosed with a biphasic lifestyle as shown by the palate shape and several non-shape features associated with the vomerine teeth, with diverse ecological types displayed in living species achieved in the Early Cretaceous.
    1. Ecology
    2. Evolutionary Biology

    Passive accumulation of alkaloids in inconspicuously colored frogs refines the evolutionary paradigm of acquired chemical defenses

    Rebecca D Tarvin, Jeffrey L Coleman ... Richard W Fitch
    The detection of low quantities of alkaloids in putatively nontoxic species of poison frogs sheds light on early evolutionary stages of chemical defense in animals.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A precisely adjustable, variation-suppressed eukaryotic transcriptional controller to enable genetic discovery

    Asli Azizoglu, Roger Brent, Fabian Rudolf
    A new gene expression tool enables precise control of protein dosage over a large range and paves the way for new genetic discoveries.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions

    Benjamin Werner, Fabian Beier ... Arne Traulsen
    Telomere length distributions can be used to infer important properties of stem cell proliferation.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

    Ananda Kishore Mukherjee, Subhajit Dutta ... Shantanu Chowdhury
    Telomere-sensitive regulation of IL1R1 by the shelterin protein TERF2 modulates tumour macrophage inflitration in triple-negative breast cancer.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch

    Sandeep K Talapatra, Bethany Harker, Julie PI Welburn
    Structural analysis of the kinesin-13 MCAK bound to its C-terminal tail reveals the molecular basis for the conformation of kinesin-13 in solution and the mechanism that triggers long-range conformational changes upon microtubule binding.
    1. Chromosomes and Gene Expression

    The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast

    Io Nam Wong, Jacqueline PS Neo ... Matthew C Whitby
    Genomic deletions formed from inter-fork strand annealing associated with a collapsed replication fork are suppressed by the FANCM-related DNA helicase Fml1 in conjunction with its partner proteins Mhf1 and Mhf2.
    1. Cancer Biology
    2. Immunology and Inflammation

    The effects of age and systemic metabolism on anti-tumor T cell responses

    Jefte M Drijvers, Arlene H Sharpe, Marcia C Haigis
    A comprehensive literature review delineates the current knowledge of how systemic context, such as age and obesity, can impact CD8+ T cell function, anti-tumor immunity, and immunotherapy responsiveness.
    1. Developmental Biology
    2. Neuroscience

    Establishment and maintenance of motor neuron identity via temporal modularity in terminal selector function

    Yinan Li, Anthony Osuma ... Paschalis Kratsios
    The terminal selector-type transcription factor UNC-3/Ebf partially modifies the suite of its target genes at different life stages to establish and maintain the identity of C. elegans motor neurons.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2

    Rosa María Marión, Juan J Montero ... Maria A Blasco
    Telomeric TRF1 controls the transcriptional programmes of pluripotent stem cells by recruiting PRC2 to pluripotency and differentiation genes by controlling the expression of those gene sites and the binding of TERRA RNAs to them.