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    1. Neuroscience

    Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology

    Harshvardhan Gazula, Henry FJ Tregidgo ... Juan E Iglesias
    New open-source software enables, for the first time, extraction of quantitative information from brain dissection photographs that are routinely taken at brain banks for archiving purposes but otherwise not exploited.
    1. Ecology

    No general relationship between mass and temperature in endothermic species

    Kristina Riemer, Robert P Guralnick, Ethan P White
    Data analysis of a large number of species indicates that a negative temperature-mass relationship is not common among species, which has been an ecological assumption for over a century.
    1. Chromosomes and Gene Expression

    The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae

    Evan P Hass, David C Zappulla
    In yeast, the secondary pathway for recruiting telomerase to chromosome ends requires a component of telomeric transcriptionally silent chromatin.
    1. Genetics and Genomics

    Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusions

    Zhi-Jing Wu, Jia-Cheng Liu ... Jin-Qiu Zhou
    Cdc13 prevents chromosomes from end-to-end fusion.
  1. Media coverage: November roundup of eLife papers in the news

    High-profile news coverage that eLife papers generated in November 2017, including CTV News, International Business Times and Smithsonian magazine.
    1. Stem Cells and Regenerative Medicine

    Cutting Edge: Promoting international collaboration and creativity in doctoral students

    Christopher M Groen, Cormac McGrath ... Natalia Landázuri
    Staff from the Mayo Clinic in the US and the Karolinska Institute in Sweden describe a joint transatlantic course intended to broaden the horizons of the next generation of researchers in the field of regenerative medicine.
    1. Neuroscience

    Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons

    Gabriel E Romero, Laurence O Trussell
    In a fast brainstem relay controlling hearing sensitivity, descending synaptic control from midbrain provides the dominant source of excitation, due to a distinct form of synaptic plasticity.
    1. Epidemiology and Global Health
    2. Medicine

    Effects of water, sanitation, handwashing, and nutritional interventions on telomere length among children in a cluster-randomized controlled trial in rural Bangladesh

    Audrie Lin, Benjamin F Arnold ... Stephen P Luby
    In a randomized controlled trial in rural Bangladesh, an intensive, combined water, sanitation, handwashing, and nutrition intervention delivered to compounds of newborn children increased telomere length attrition during their first year of life.
    1. Chromosomes and Gene Expression

    Rif2 protects Rap1-depleted telomeres from MRX-mediated degradation in Saccharomyces cerevisiae

    Fernando Rodrigo Rosas Bringas, Sonia Stinus ... Michael Chang
    Telomere-specific depletion of Rap1, the main sequence-specific telomere-binding protein in Saccharomyces cerevisiae, can be tolerated due to the presence of secondary telomere capping mechanisms, which may help explain the rapid evolution of budding yeast telomeres.
    1. Chromosomes and Gene Expression

    The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis

    Roland Ivanyi-Nagy, Syed Moiz Ahmed ... Peter Dröge
    A messenger RNA coding for the histone 1.2 protein negatively regulates telomere elongation by interacting with human telomerase RNA.