Upon DNA damage, Rad52 forms a membraneless sub-compartment where Rad52 molecules are highly dynamic and share properties with liquid-liquid phase-separated molecules, reflecting the existence of a liquid droplet around damaged DNA.
Jonathan Gilley, Oscar Jackson ... Michael P Coleman
Rare SARM1 alleles encoding SARM1 variants that have constitutively high NADase activity and sensitise cultured neurons to mild stress are risk alleles for ALS and other, related motor disorders.
Katherine G Zyner, Darcie S Mulhearn ... Shankar Balasubramanian
For the first time, the spectrum of genes and pathways interacting with alternative DNA structures called G-quadruplexes in humans is revealed highlighting new possibilities for the pursuit of cancer therapies.
Genetics and genomics approaches reveal a conserved post-transcriptional regulatory mechanism that promotes adult axon regeneration from worm to mammals.
The cannabinoids cannabidiol, cannabidivarin, and the newly identified 331-18A demonstrate antitumoral effects in Notch1-mutated leukemia, underscoring the potential and complexity of Cannabis as a novel treatment for cancer.
Luis F Sifuentes-Dominguez, Haiying Li ... Ezra Burstein
A novel mutation in SCGN is associated with risk for inflammatory bowel disease and implicates the intestinal neuroendocrine compartment in the pathogenesis of this disorder.
Nearly half of bladder cancers of solid organ transplant recipients harbor papillomaviruses or polyomaviruses, with many tumors showing evidence of clonal viral integration and viral oncogene effects on tumor gene expression patterns.
The newly developed antibody-free techniques, HepG4-seq for G-quadruplexes and HBD-seq for R-loops, robustly reveal the comprehensive maps of native G-quadruplexes and R-loops, as well as their roles in transcriptional regulation.
An integrated empirical paradigm tracing immune strategies, underlying mechanisms and infection outcomes across reservoir host-pathogen systems, their specific ecological contexts, life-history features, and coevolutionary dynamics can reveal the actual patterns and processes underlying spillover in the wild.
Whole-night fMRI-based sleep classification uncovers distinct substates within N2 and REM sleep stages, along with a transition structure between them.
