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    1. Epidemiology and Global Health
    2. Plant Biology

    Evolutionary transitions between beneficial and phytopathogenic Rhodococcus challenge disease management

    Elizabeth A Savory, Skylar L Fuller ... Jeff H Chang
    The horizontal acquisition of virulence plasmids is potentiated by production practices in plant nurseries and is sufficient to transition Rhodococcus from being beneficial to being pathogenic.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases

    Cosimo Pinto, Kristina Kasaciunaite ... Petr Cejka
    The nuclease of hDNA2 limits its processive DNA unwinding capacity; the helicase function becomes stimulatory when hDNA2 is in complex with BLM or WRN helicase to degrade dsDNA.
    1. Genetics and Genomics

    Variation in ubiquitin system genes creates substrate-specific effects on proteasomal protein degradation

    Mahlon A Collins, Gemechu Mekonnen, Frank Wolfgang Albert
    Genetic mapping reveals widespread, complex genetic effects on protein degradation by the ubiquitin-proteasome system, the primary protein degradation pathway in eukaryotic cells.
    1. Neuroscience

    Brainstem network dynamics underlying the encoding of bladder information

    Anitha Manohar, Andre L Curtis ... Rita J Valentino
    Neural and network activity within a pontine-cortical micturition circuit are finely coordinated with urodynamics to assure appropriate voiding behaviors.
    1. Ecology
    2. Evolutionary Biology
    Zebrafish illustration

    The Natural History of Model Organisms: Advancing biology through a deeper understanding of zebrafish ecology and evolution

    David M Parichy
    The zebrafish is a premier model organism for biomedical research, with a rich array of tools and genomic resources, and combining these with a fuller appreciation of wild zebrafish ecology could greatly extend its utility in biological research.
    1. Chromosomes and Gene Expression

    Catastrophic chromosomal restructuring during genome elimination in plants

    Ek Han Tan, Isabelle M Henry ... Simon WL Chan
    Complex chromosomal rearrangements similar to those described in cancer and developmental syndromes occur in plants during postzygotic genome elimination, a centromeric-derived incompatibility.
    1. Cell Biology
    2. Neuroscience

    Tadr is an axonal histidine transporter required for visual neurotransmission in Drosophila

    Yongchao Han, Lei Peng, Tao Wang
    TADR (torn and diminished rhabdomeres)-dependent histidine transporting is required for de novo synthesis of histamine and for maintaining synaptic transmission of photoreceptor neurons in Drosophila.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity

    Xue-Song Zhang, Jackie Li ... Martin J Blaser
    Alteration of host gut microbiota by antibiotic exposure in early life remodeled host intestinal immune development and metabolism and enhanced the induction of type 1 diabetes in genetically predisposed animals.
    1. Neuroscience

    Microstructural asymmetries of the planum temporale predict functional lateralization of auditory-language processing

    Peipei Qin, Qiuhui Bi ... Gaolang Gong
    The important role of structural asymmetry in the functional lateralization of the same brain area provides a crucial insight into the neurobiological fundament for human brain's functional lateralization.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Modulation of biophysical properties of nucleocapsid protein in the mutant spectrum of SARS-CoV-2

    Ai Nguyen, Huaying Zhao ... Peter Schuck
    Exploration of the phenotype space corresponding to the sequence space of viable SARS-CoV-2 nucleocapsid protein species reveals significant diversity of biophysical characteristics, nonlocal mutation effects, and functional constraints.