Bodo saltans virus defines the most abundant giant viruses in the ocean and highlights the genomic plasticity, rooted in evolutionary arms races, that gave rise to giant viruses.

Strategies to improve public trust in biomedical research are being hindered by a scientific mindset that stifles interest in reform.

The rat is much more than a simple model, and a better appreciation of the natural history of wild rats would increase its value as a research organism.

Exercise can induce metabolic changes that strikingly impact cytotoxic T cell function and in turn affect cancer progression.

Structural analysis of translating human mitoribosome illustrates elemental steps of translation in mitochondria.

Genetic analyses illustrate the novel requirement of Ftz-f1 and Sim in adult Drosophila ovaries for regulating follicle cell differentiation and ovulation that is likely conserved in mammals.

The RAB-28 GTPase regulates ciliary extracellular vesicle shedding, which may be important for neuron-glia communication.

The tubulin GTPase cycle structurally modulates the microtubule cap, causing lattice expansion, which is an intermediate state involved in phosphate release and regulatory signaling.

Systematic CRISPR-based editing of tRNA genes revealed that different human cells that span a range of growth rates and different modes of proliferation states require diverse tRNA sets.

A novel bacterial deubiquitinase with multiple chain types specificity regulates the association of ubiquitinated proteins on the phagosome of Legionella pneumophila.