Bodo saltans virus defines the most abundant giant viruses in the ocean and highlights the genomic plasticity, rooted in evolutionary arms races, that gave rise to giant viruses.

The rat is much more than a simple model, and a better appreciation of the natural history of wild rats would increase its value as a research organism.

Systematic CRISPR-based editing of tRNA genes revealed that different human cells that span a range of growth rates and different modes of proliferation states require diverse tRNA sets.

The tubulin GTPase cycle structurally modulates the microtubule cap, causing lattice expansion, which is an intermediate state involved in phosphate release and regulatory signaling.

Folding and unfolding of a 6-helix bundle controls HIV assembly and maturation.

An ensemble of cryo-EM structures reveals how eukaryotic elongation factor 2 positions the first codon of a viral mRNA for translation.

The Chip/LDB-SSDP complex integrates multiple signals to render TCF/LEF enhancers Wnt responsive.

The well-established link between stress and depression could be due to the activity of a population of cells in prefrontal cortex that express a gene mutated in the rare disorder Wolfram syndrome.

Heme accumulation is toxic, but deficiency of the heme transporter HRG1/SLC48A1 causes heme sequestration and crystallization into hemozoin within enlarged lysosomes of macrophages, thereby conferring heme tolerance to mammals.

Rostromedial tegmental neurons encode motivational valence and opponent responses across a wide range of affective stimulus modalities, while also driving dopamine inhibition and conditioned place aversion to aversive stimuli.