245 results found
    1. Neuroscience

    Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons

    Patrícia A Correia, Eran Lottem ... Zachary F Mainen
    Phasic activation of dorsal raphe serotonin neurons transiently inhibits locomotion without influencing anxiety or producing reinforcement, but when repeated over many days a long-term facilitation of locomotion is produced.
    1. Ecology

    Drivers of species knowledge across the tree of life

    Stefano Mammola, Martino Adamo ... Ricardo A Correia
    Different species-level characteristics and sociocultural factors influence scientific and societal interest in biodiversity, with important implications for species-level conservation and dissemination.
    1. Evolutionary Biology
    2. Medicine

    The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis

    Rion Brattig-Correia, Joana M Almeida ... Paulo Navarro-Costa
    An interdisciplinary research platform reveals that the transcriptional identity of metazoan male germ cells is built around a small network of deeply conserved gene interactions with an overarching functional impact.
    1. Microbiology and Infectious Disease

    Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission

    Anne L Sapiro, Beth M Hayes ... Seemay Chou
    Development of an enrichment method to facilitate RNA-sequencing of the Lyme disease pathogen from inside of ticks during a bloodmeal provides new candidates for genes important for disease transmission.
    1. Neuroscience

    Diverse modes of synaptic signaling, regulation, and plasticity distinguish two classes of C. elegans glutamatergic neurons

    Donovan Ventimiglia, Cornelia I Bargmann
    Single-neuron synaptic imaging in vivo demonstrates that highly conserved molecules such as UNC-13, UNC-18, and protein kinase C, which are found at essentially every synapse make different functional contributions in Caenorhabditis elegans glutamatergic neurons.
    1. Neuroscience

    Hippocampal-occipital connectivity reflects autobiographical memory deficits in aphantasia

    Merlin Monzel, Pitshaporn Leelaarporn ... Cornelia McCormick
    The autobiographical memory deficits seen in aphantasia are reflected by altered activation and connectivity patterns of the hippocampus and occipital cortex, corroborating the strong link between memory and mental imagery.
    1. Neuroscience

    Reliability of an interneuron response depends on an integrated sensory state

    May Dobosiewicz, Qiang Liu, Cornelia I Bargmann
    A pair of interneurons in C. elegans condenses information from multiple sensory neurons into a uniform response, using an AND-gate logic to represent a stimulus with positive valence.
    1. Neuroscience

    GABA, not BOLD, reveals dissociable learning-dependent plasticity mechanisms in the human brain

    Polytimi Frangou, Marta Correia, Zoe Kourtzi
    Combining GABA with fMRI measurements in the human brain uncovers distinct suppression mechanisms that optimize perceptual decisions through learning and experience-dependent plasticity in the visual cortex.
    1. Genetics and Genomics
    2. Neuroscience

    Sensory neurons couple arousal and foraging decisions in Caenorhabditis elegans

    Elias Scheer, Cornelia I Bargmann
    A long-term arousal state is linked to the acute decision to leave a food patch by sensory neurons that integrate neuromodulatory information, food intake, and environmental signals.
    1. Neuroscience

    Behavioral control by depolarized and hyperpolarized states of an integrating neuron

    Aylesse Sordillo, Cornelia I Bargmann
    Precise genetic manipulations demonstrate that a single-neuron class dynamically controls multiple behaviors by engaging different synapses during high- and low-activity states.

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