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    1. Neuroscience
    2. Genetics and Genomics

    Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foraging behavior

    Joshua S Greene, May Dobosiewicz ... Cornelia I Bargmann
    A quantitative trait locus that includes two pheromone receptor genes affects foraging behavior; for one of the genes, the two alleles of the QTL have opposite effects because of distinct sites of expression.
    1. Neuroscience

    Parallel encoding of sensory history and behavioral preference during Caenorhabditis elegans olfactory learning

    Christine E Cho, Chantal Brueggemann ... Cornelia I Bargmann
    Odor conditioning induces two changes in olfactory neurons: non-associative sensory adaptation to odor history, and associative, bidirectional changes in behavioral output that are oppositely regulated in aversive and appetitive learning.
    1. Neuroscience

    Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis

    Kwun Nok M Man, Cordelia Imig ... Sonja M Wojcik
    Munc13 proteins are key determinants of large dense-core vesicle (LDCV)-dependent catecholamine release in chromaffin cells.
    1. Developmental Biology

    Pak1 and PP2A antagonize aPKC function to support cortical tension induced by the Crumbs-Yurt complex

    Cornelia Biehler, Katheryn E Rothenberg ... Patrick Laprise
    Cell biology analyses in Drosophila epithelial tissues reveal novel mechanisms connecting epithelial polarity proteins with Myosin-dependent cell contractility.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The infection-tolerant white-footed deermouse tempers interferon responses to endotoxin in comparison to the mouse and rat

    Ana Milovic, Jonathan V Duong, Alan G Barbour
    Comparing the white-footed deermouse with mice and rats in an inflammation model reveals a means for the observed infection tolerance in this key animal reservoir for several human diseases.
    1. Evolutionary Biology

    Fog signaling has diverse roles in epithelial morphogenesis in insects

    Matthew Alan Benton, Nadine Frey ... Siegfried Roth
    Fog signaling with a narrow morphogenetic role in Drosophila has a deeply conserved function in epithelial morphogenesis across insects.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Rhodoquinone biosynthesis in C. elegans requires precursors generated by the kynurenine pathway

    Samantha Del Borrello, Margot Lautens ... Andrew G Fraser
    Parasitic helminths infect over a billion humans and use unusual anaerobic metabolism that needs a rare electron carrier, Rhodoquinone (RQ), whose synthesis requires the kynurenine pathway of tryptophan degradation.
    1. Cell Biology
    2. Neuroscience

    Combining array tomography with electron tomography provides insights into leakiness of the blood-brain barrier in mouse cortex

    Georg Kislinger, Gunar Fabig ... Martina Schifferer
    An array tomography and electron tomography hybrid approach based on coated plastic tape as support advances ultrastructural analysis of biological phenomena that require cell- and tissue-level contextualization of the finest subcellular textures.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural insights into flagellar stator–rotor interactions

    Yunjie Chang, Ki Hwan Moon ... Jun Liu
    In situ structural analysis of bacterial flagellar motor in the Lyme disease spirochete reveals novel conformational change driven by proton motive force.
    1. Neuroscience

    Amygdala-ventral striatum circuit activation decreases long-term fear

    Susana S Correia, Anna G McGrath ... Ki A Goosens
    Behavior- or optogenetic-driven activation of a basolateral amygdala projection to the nucleus accumbens enhances infralimbic cortex activity and long-term fear extinction.