2,035 results found
    1. Neuroscience

    Long-term adult human brain slice cultures as a model system to study human CNS circuitry and disease

    Niklas Schwarz et al.
    Viral transduction and gene manipulation of adult human brain slices will be of great value allowing investigations including therapeutic screening, electrophysiological and structural studies of properties of human CNS circuitry.
    1. Evolutionary Biology

    Neurocranial anatomy of an enigmatic Early Devonian fish sheds light on early osteichthyan evolution

    Alice M Clement et al.
    Stunning new scan data of an enigmatic fish from the Early Devonian of Australia, Ligulalepis, is identified as a stem osteichthyan, specifically, as the sister taxon to the 'psarolepids' plus crown osteichthyans.
    1. Neuroscience
    2. Physics of Living Systems

    Revealing architectural order with quantitative label-free imaging and deep learning

    Syuan-Ming Guo et al.
    Advances in quantitative phase and polarized light microscopy, combined with deep learning, reveal the architecture of human brain tissue.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons

    Stephanie C Gantz et al.
    In mouse brain slices, native delta glutamate receptors carry ionic current and underlie the α1-adrenergic receptor-mediated depolarization of dorsal raphe neurons that drives action potential firing in vivo.
    1. Neuroscience

    Orphan receptor GPR158 controls stress-induced depression

    Laurie P Sutton et al.
    The orphan receptor GPR158 is highly regulated by stress exposure and acts on key neuronal signaling pathways in the prefrontal cortex to control depressive-like behaviors.
    1. Neuroscience

    High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp

    Yangfan Peng et al.
    Combining a multineuron patch-clamp system with an automated pipette pressure and cleaning device enables efficient screening of synaptic connectivity in human brain slices and allows inter-individual comparison.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract

    Koning Shen et al.
    The polyQ tract of pathogenic Huntingtin causes aggregation when expanded in Huntington’s disease, but its two flanking domains control its conformational landscape, proteostasis and neurotoxicity.
    1. Neuroscience

    BAD and KATP channels regulate neuron excitability and epileptiform activity

    Juan Ramón Martínez-François et al.
    Altered activity of ATP-sensitive K+ channels underlies the metabolic seizure resistance produced by genetic manipulation of the BAD protein in mice.
    1. Neuroscience

    Interaction of plasticity and circuit organization during the acquisition of cerebellum-dependent motor learning

    Yan Yang, Stephen G Lisberger
    During learning, one climbing fiber input instructs plasticity that is expressed in the simple-spike responses of cerebellar Purkinje cells, and causes neural learning that may inhibit future climbing fiber instructions.
    1. Neuroscience

    Retroactive modulation of spike timing-dependent plasticity by dopamine

    Zuzanna Brzosko et al.
    Dopamine, a reward signal in the brain, can retroactively convert hippocampal synaptic depression into potentiation, suggesting an elegant biological solution to the distal reward problem.

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