High-definition anodal transcranial stimulation alleviated cognitive deficits, affected dopaminergic neurotransmission factors, increased expression of several neurotrophic factors involving brain-derived neurotrophic factor (BDNF), and activated hippocampal neurogenesis.

RAI1 regulates molecular signalling and intrinsic excitability of hypothalamic brain-derived neurotrophic factor neurons important for energy homeostasis.

The established triple co-culture blood-–brain barrier (BBB) model could be used for predicting drugs’ BBB permeability, and co-culture with neurons and astrocytes enhanced brain endothelial cells’ integrity by secreting GDNF, which upregulated claudin-5 and VE-cadherin expression.

Brain-derived neurotrophic factor signaling plays a causal role in female-typical social behavior and modulates oxytocin neuron gene expression.

A potential link between metabolic changes resulting from exercise and gene expression in the brain has been revealed.

BDNF-regulated deployment of Rab10 to the distal axon regulates retrograde propagation of neurotrophic signalling, providing a flexible mechanism to fine-tune the communication between the synapse and the cell body of neurons, as well as novel therapeutic targets for neurodegeneration.

Brain-derived neurotrophic factor (BDNF)/TrkB.T1 signaling contributes to astrocyte morphological maturation, with implications for neuronal synaptogenesis and function and astrocyte functional maturation.

An evolutionarily conserved neuron-specific and stimulus-dependent enhancer region downstream of the Bdnf exon III regulates the expression of Bdnf transcripts starting from the upstream 5' exons.

Synaptic silencing-induced homeostatic enhancement of presynaptic glutamate release is mediated by the postsynaptic retinoic acid-dependent brain-derived neurotrophic factor (BDNF) synthesis from dendritically targeted BDNF transcripts, leading to retrograde activation of presynaptic tropomyosin receptor kinase B receptors.

Overexpression of the growth factor neurotrophin-3 helps to repair noise-induced damage in the mouse inner ear by promoting the regeneration of damaged synapses.