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Comparisons between the ON- and OFF-edge motion pathways in the
Kazunori Shinomiya et al.
A complete connectome of the ON and OFF motion pathways of the
optic lobe is acquired using three-dimensional EM methods, and the similarities and differences of the two pathways are uncovered.
Radially patterned cell behaviours during tube budding from an epithelium
Yara E Sanchez-Corrales et al.
Quantitative analysis in quasi-3D reveals apically driven cell behaviours that are closely coordinated across the tissue to allow ordered tube invagination through a focal point.
Immunology and Inflammation
Capturing change in clonal composition amongst single mouse germinal centers
Daniel J Firl et al.
Repeated interrogation of single germinal centers in vivo reveals a more fluid landscape than expected and unlocks new lines of investigation.
Mamo decodes hierarchical temporal gradients into terminal neuronal fate
Ling-Yu Liu et al.
Neuronal diversity is expanded by a temporal fating paradigm utilizing hierarchical gene regulation.
Single-exposure visual memory judgments are reflected in inferotemporal cortex
Travis Meyer, Nicole C Rust
In response to the question "Have you seen this image before?", remembering and forgetting can be accounted for by a weighted linear read-out of memory signals in monkey inferotemporal cortex.
Landscape genomic prediction for restoration of a
foundation species under climate change
Megan Ann Supple et al.
Empirical patterns of genomic and phenotypic variation across the landscape are used to develop a predictive model that will help build resilient ecological communities.
Nucleophile sensitivity of
TRPA1 underlies light-induced feeding deterrence
Eun Jo Du et al.
Electron-donating nucleophilic compounds activate TRPA1 ion channels in fruit flies and mosquitoes, but not humans, making TRPA1 a promising target for insect repellants.
Human intracranial recordings link suppressed transients rather than 'filling-in' to perceptual continuity across blinks
Tal Golan et al.
The brain ensures that blinks do not disrupt vision by deleting signals that represent discontinuities in visual input, rather than by recreating the missing input.
The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells
Anjali Teckchandani, Jonathan A Cooper
A ubiquitin E3 ligase localizes to focal adhesions at the front of migrating human cells where it regulates cytoskeletal dynamics by targeting a focal adhesion protein.
The carcinine transporter CarT is required in
photoreceptor neurons to sustain histamine recycling
Drew Stenesen et al.
Fly vision depends on a member of the SLC22 transporter family for recycling the histamine neurotransmitter following its uptake by glia and its modification into the transport metabolite carcinine.
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