8 results found
    1. Immunology and Inflammation

    Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses

    Yujie Fang, Zihan Guan ... Ke Peng
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Ecology
    2. Epidemiology and Global Health

    Mosquito community composition shapes virus prevalence patterns along anthropogenic disturbance gradients

    Kyra Hermanns, Marco Marklewitz ... Sandra Junglen
    Analysis of naturally infected mosquitoes shows that ecosystem disturbance can lead to a turnover in host community composition and that more individuals of a single species are a key driver of virus emergence.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Single mosquito metatranscriptomics identifies vectors, emerging pathogens and reservoirs in one assay

    Joshua Batson, Gytis Dudas ... Hanna Retallack
    How large-scale single mosquito metatranscriptomics can define the mosquito’s complex microbiota and its blood meal sources, and contribute critical epidemiological information needed to control vector borne disease transmission, is shown.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Immunocompetent mouse model for Crimean-Congo hemorrhagic fever virus

    David W Hawman, Kimberly Meade-White ... Heinz Feldmann
    A mouse-adapted strain of Crimean-Congo hemorrhagic fever virus that recapitulates human disease in wild-type mice significantly improves our ability to study Crimean-Congo hemorrhagic fever virus pathogenesis.
    1. Microbiology and Infectious Disease

    Multimeric single-domain antibody complexes protect against bunyavirus infections

    Paul J Wichgers Schreur, Sandra van de Water ... Jeroen Kortekaas
    Llama-derived single-domain antibodies, formatted as bispecific antibodies with human Fc domains, reduce and prevent bunyavirus-induced morbidity and mortality in mice upon prophylactic and therapeutic administration.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Molecular organization and dynamics of the fusion protein Gc at the hantavirus surface

    Eduardo A Bignon, Amelina Albornoz ... Nicole D Tischler
    Hantavirus spikes are related laterally by 2-fold Gc contacts that can be disulfide-linked and display a temperature-dependent dynamic behavior at neutral pH, exposing and masking the Gc fusion loops.
    1. Structural Biology and Molecular Biophysics

    High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms

    Benoît Arragain, Juan Reguera ... Hélène Malet
    Hantaan virus nucleocapsid cryo-EM structure determined at 3.3 Å resolution reveals how nucleoproteins assemble into a metastable helix containing a continuous RNA-binding groove compatible with genome encapsidation and compaction.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments

    Michal Barski, Benjamin Brennan ... Ulrich Schwarz-Linek
    Insight into the molecular assembly of a protein with a central role in infections paves the way to understanding how Rift Valley fever virus causes disease.

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