Integrated ecological and genetic methods show that Bursicon signaling pathway and miR-6012 regulate the transition from summer-form to winter-form in Cacopsylla chinensis through affecting cuticle pigment and cuticle thickness.

The elementary units of a fruit fly behavioral sequence are described at single-muscle resolution and shown to exhibit variability that is subject to neuromodulatory regulation.

Evolutionary reconstruction of the ecdysis pathway shows that its major elements are present in the majority of metazoans, providing evidence that they originated much earlier than currently assumed.

The response of the peptidergic neurons that control a stereotyped behavior depends on the actions of a triggering neuropeptide, downstream neuropeptides and GABA inhibitory influences.

Using targeted functional manipulations of neural activity to map neuromodulatory connections can deliver considerable insight into the functional architecture of a behaviorally important network even in the absence of information about its synaptic connectivity.

A combination of electron microscopic reconstruction and the analysis of single cell transcriptome data is used to reconstruct synaptic and peptidergic signaling networks in a neurosecretory centre.

mRNA decapping function in neuronal cells regulates neurosecretion and intertissue signaling, affecting developmental and ageing processes in two model organisms.

A series of genetically-encoded fluorescent reporters that allow imaging of neuropeptide release in vivo, with sub-second temporal and nerve terminal-level spatial resolution are developed.

The identification of 31 neuropeptide GPCRs in the sea anemone Nematostella vectensis provides a rich resource to study peptidergic signaling in cnidarians and suggests that cnidarian and bilaterian peptidergic systems diversified independent from each other from a few ancestral systems.

A genetic method allows neurons to be individually identified and characterized by combining information about both their developmental origins and their mature patterns of gene expression.