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    1. Cell Biology
    2. Developmental Biology

    Sex determination gene transformer regulates the male-female difference in Drosophila fat storage via the adipokinetic hormone pathway

    Lianna W Wat, Zahid S Chowdhury ... Elizabeth J Rideout
    Drosophila females store more fat than males because the presence of a functional Transformer protein in females limits adipokinetic hormone production and pathway activity.
    1. Neuroscience

    Peptidoglycan-dependent NF-κB activation in a small subset of brain octopaminergic neurons controls female oviposition

    Ambra Masuzzo, Gérard Manière ... Julien Royet
    The universal bacteria cell wall component peptidoglycan impacts the egg-laying behavior of infected Drosophila females by directly modulating the activity of few brain octopaminergic neurons.
    1. Developmental Biology

    Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development

    Angela J Churchill, Giselle Dominguez Gutiérrez ... Lori Sussel
    The regulation of beta cell induction requires combined hierarchical and combinatorial transcriptional networks.
    1. Cell Biology

    ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals

    Natalya Pashkova, Lokesh Gakhar ... Robert C Piper
    The family of ANTH domain proteins serve as adaptors to endocytose ubiquitinated proteins from the cell surface.
    1. Cell Biology

    COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal

    Peng Xu, Hannah M Hankins ... Todd R Graham
    COPI vesicle coat protein recognizes a ubiquitin sorting signal on an exocytic v-SNARE to mediate recycling.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Insights into early animal evolution from the genome of the xenacoelomorph worm Xenoturbella bocki

    Philipp H Schiffer, Paschalis Natsidis ... Maximilian J Telford
    A genome analysis of Xenoturbella bocki provides insights into the biology of this enigmatic marine worm and enhances our understanding of early bilaterian evolution.
    1. Neuroscience

    A dopamine-gated learning circuit underpins reproductive state-dependent odor preference in Drosophila females

    Ariane C Boehm, Anja B Friedrich ... Ilona C Grunwald Kadow
    Behavioral and in vivo imaging analysis in the fly suggests that mating-related sensory experience regulates female odor perception and expression of choice behavior through a dopamine-gated learning circuit.
    1. Epidemiology and Global Health

    Ebola virus disease in the Democratic Republic of the Congo, 1976-2014

    Alicia Rosello, Mathias Mossoko ... Jean-Jacques Muyembe Tamfum
    Analysing a compilation of individual-level data gathered across the seven Ebola Virus Disease outbreaks in the Democratic Republic of the Congo reveals factors that contribute to the spread of the disease and mortality.
    1. Medicine

    Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams–Beuren syndrome

    Alba Navarro-Romero, Lorena Galera-López ... Andres Ozaita
    A mouse model of Williams–Beuren syndrome allowed us to assess the endocannabinoid system and the impact of targeting the monoacyl glycerol lipase in modulating key phenotypes such as cognitive and hypersocial phenotype as well as the cardiac phenotype.
    1. Cell Biology

    The AP-2 complex has a specialized clathrin-independent role in apical endocytosis and polar growth in fungi

    Olga Martzoukou, Sotiris Amillis ... George Diallinas
    In filamentous fungi the AP-2 complex, which in mammals is an adaptor of clathrin-mediated endocytosis, is recruited to specific clathrin-independent apical endocytosis necessary for proper lipid maintenance and polar growth.