To leverage the tools, resources and knowledge that exist for C. elegans so that we can study ecology, evolution and other aspects of biology, we need to understand the natural history of this important model organism.
A series of quantitative behavioural and opto-physiological analyses using a novel robot microscope system reveals that C. elegans computes the time-differential and time-integral of sensory information for decision-making during olfactory navigation.
Genetic analysis of how neuropeptides control C. elegans reproductive behavior shows how T-type calcium channels engage and disengage target neurons from these critical regulators of neural circuits and behavior.
Analyzing a map of all cholinergic neurons in the nematode C. elegans shows how these neurons are embedded in the C. elegans connectome and reveals the regulatory factors controlling their development.
Inhibition of C. elegans FLD-1 or Human TLCD1/2 prevents saturated fat lipotoxicity by allowing increased levels of membrane phospholipids that contain fluidizing long-chain polyunsaturated fatty acids.