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    1. Neuroscience

    Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans

    Jing Yan, Dan L Chao ... Kang Shen
    A cellular motor protein helps to ensure that microtubules are oriented correctly within neuronal dendrites
    1. Developmental Biology
    2. Neuroscience

    LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans

    Pengpeng Li, Kevin M Collins ... Kang Shen
    The Notch signaling pathway has a central role in the formation of the circuit that controls egg-laying in the nematode worm C. elegans.
    1. Developmental Biology
    2. Neuroscience

    Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish

    Ankur Saxena, Brian N Peng, Marianne E Bronner
    Sensory neurons in the olfactory system develop from two different regions of the ectoderm, the olfactory placode and the cranial neural crest, whereas sensory neurons within the eye and ear develop from just one region.
    1. Plant Biology
    2. Developmental Biology

    Sugar is an endogenous cue for juvenile-to-adult phase transition in plants

    Sha Yu, Li Cao ... Jia-Wei Wang
    Sugar levels in leaves act as a signal for plants to switch from their juvenile to their adult form by regulating the expression of two genes.
    1. Developmental Biology
    2. Plant Biology

    Sugar promotes vegetative phase change in Arabidopsis thaliana by repressing the expression of MIR156A and MIR156C

    Li Yang, Mingli Xu ... R Scott Poethig
    Sugar levels in leaves act as a signal for plants to switch from their juvenile to their adult form by regulating the expression of two genes.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Mechanism for priming DNA synthesis by yeast DNA Polymerase α

    Rajika L Perera, Rubben Torella ... Luca Pellegrini
    The details of how the enzyme DNA polymerase α initiates the polymerization of nucleotides in DNA replication, a critical step in the synthesis of new chromosomal DNA, have been revealed in atomic detail.
    1. Cell Biology

    The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress

    Yingying Zhao, Jason A MacGurn ... Scott Emr
    Ubiquitin ligase adaptors target the selective clearance of misfolded plasma membrane proteins.
    1. Cell Biology
    2. Cancer Biology

    A role for PVRL4-driven cell–cell interactions in tumorigenesis

    Natalya N Pavlova, Christian Pallasch ... Stephen J Elledge
    A protein called PVRL4 has a central role in a number of cancers that originate in epithelial tissue, and anti-PVRL4 antibodies could be used to treat some of these cancers.
    1. Developmental Biology

    A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans

    Huanhu Zhu, Huali Shen ... Min Han
    A lipid acts to promote the development of nematode worm larvae through activation of an enzyme complex called TORC1.
    1. Epidemiology and Global Health

    Predicting mosquito infection from Plasmodium falciparum gametocyte density and estimating the reservoir of infection

    Thomas S Churcher, Teun Bousema ... María-Gloria Basáñez
    Identifying and treating those groups of individuals that are most likely to transmit the malaria parasite to mosquitoes could help to control the spread of the disease.