38 results found
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway

    Bin Z He et al.
    The phosphate starvation response network in a commensal yeast evolved to expand its downstream targets via changes in the main transcription factor's dependence on its co-activator, potentially altering the physiological response.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Alternative splicing of coq-2 controls the levels of rhodoquinone in animals

    June H Tan et al.
    The switch from ubiquinone to rhodoquinone synthesis that is required for parasitic helminths to survive in anaerobic host tissues is due to alternative splicing of polyprenyltransferase COQ-2.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Clusters of polymorphic transmembrane genes control resistance to schistosomes in snail vectors

    Jacob A Tennessen et al.
    A region of the Biomphalaria genome, containing highly divergent haplotypes with different combinations of transmembrane genes, strongly impacts whether these snails can transmit parasitic schistosomes.
    1. Microbiology and Infectious Disease

    Coordination of humoral immune factors dictates compatibility between Schistosoma mansoni and Biomphalaria glabrata

    Hongyu Li et al.
    A coordinated humoral immune response that includes recognition, effector and cytotoxic factors engages the cell-mediated immune response to defend a snail against infection by schistosome parasites.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Communication between distinct subunit interfaces of the cohesin complex promotes its topological entrapment of DNA

    Vincent Guacci et al.
    The interface formed where Smc3p and Mcd1p bind each other regulates cohesin DNA binding and cohesion by a mechanism independently from its putative role as a DNA exit gate.
    1. Microbiology and Infectious Disease

    Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli

    Toon Swings et al.
    Population mutation rates are highly flexible and evolvable under extreme stress conditions, matching changes in selective pressure to avoid extinction of the entire population.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Polo-like kinase Cdc5 regulates Spc72 recruitment to spindle pole body in the methylotrophic yeast Ogataea polymorpha

    Hiromi Maekawa et al.
    Cdc5-dependent SPB regulation is linked to delayed cytoplasmic microtubule organization in Ogataea polymorpha.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Intrinsic cooperativity potentiates parallel cis-regulatory evolution

    Trevor R Sorrells et al.
    Cooperativity between two transcription regulators occurs through protein-protein interactions with a general transcription factor complex and potentiates the parallel evolution of their DNA binding sites.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast

    James E Hughes Hallett et al.
    The key Target of Rapamycin Complex (TORC1) component Kog1 moves into bodies during glucose starvation to limit reactivation of the complex.
    1. Genetics and Genomics

    The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay

    Karole N D'Orazio et al.
    Cue2 is an endonuclease that cleaves mRNA in the A site of the lagging ribosome upon ribosome collision events.

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