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NALCN and TRPC6 drive the subthreshold depolarization of VTA DA neurons and down regulation of TRPC6 contributes to reduced VTA DA neuron firing and chronic stress-induced depression-like behavior of mice.

Structural analysis of the kinesin-13 MCAK bound to its C-terminal tail reveals the molecular basis for the conformation of kinesin-13 in solution and the mechanism that triggers long-range conformational changes upon microtubule binding.

GABAergic neurons in the nervous system of C. elegans have been comprehensively mapped allowing analysis of regulatory factors that program GABAergic neuron identity.

Dual FAK/PYK2 kinase inhibition disrupts GSK3β phosphorylation and may present a new treatment for colorectal cancer in patients carrying APC mutations.

An in-depth metagenomic analysis of possibly the most abundant and widespread microbial lineage in the surface ocean teases apart evolutionary processes that maintain its genomic heterogeneity and biogeography.

The crenarchaeon Sulfolobus synthesizes the N-glycan core in the identical way as all Eukaryotes, which strengthens the hypothesis that the eukaryotic N-glycosylation is acquired from an ancient archaeon during eukaryogenesis.

The bacterium Chlamydia trachomatis, a human pathogen, hijacks its host’s energy supplies by using the parasitophorous vacuole as a glycogen synthesis and storage compartment.

Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.

By combining structure-based computational predictions and a thorough structural analysis, a highly thermostable enzyme, alcohol dehydrogenase, has been engineered.

Opposing activities of ATR kinase and PP4 phosphatase balance phosphorylation of the protein DSB-1 to produce sufficient but not excessive amount of DNA double-strand breaks during meiotic prophase in Caenorhabditis elegans.