Molecular genetic, cell culture as well as electrophysiological analyses reveal a C1ql2/Neurexin3(25b+)-dependent molecular pathway through which Bcl11b controls critical functions of adult hippocampal mossy fiber synapses.

A new tick metabolic pathway that is connected to the survival of the Lyme disease spirochete was identified, which may lead to new ways to interfere with the spirochete life cycle.

A combination of mouse genetics and biochemistry approaches reveals neurexophilin4 (Nxph4) as a context-specific α-neurexin ligand, which regulates Golgi-granule cell inhibitory synapses and motor functions.

A novel pair of isobaric crosslinking reagents is described, which allow relative quantification of crosslinker-modified peptides during mass spectrometry analysis for comparative structural studies of proteins and protein complexes.

Isl2 orchestrates specific hindlimb motor pool arrangement, guaranteeing accurate motor control and sensorimotor circuit functionality.

A model of in vitro human corticogenesis identifies alterations in gene expression caused by loss of 16p11.2 CNV genes in hiPSC-derived progenitor cells.

Forniceal deep brain stimulation is a promising treatment for several neuropsychiatric disorders as it upregulates synaptic and neurogenesis-associated genes, normalizes genes misregulated in Rett syndrome mice, and regulates genes altered in intellectual disability and major depression.