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Genetic and electrophysiology experiments provide the first direct evidence that protein kinase C is a calcium-sensing protein in post-tetanic potentiation, a form of synaptic plasticity that supports short-term memory.

The structures of full-length Las1-Grc3 complexes provide crucial insights into the activation mechanism of HEPN nuclease and the pathway of pre-rRNA processing in ribosome biosynthesis.

Munc13 C-terminal domains synergize to coordinate synaptic vesicle docking, priming and fusion.

Head-to-head interactions of regulatory coiled-coil domains control activity of the central bacterial AAA+ protein ClpC by promoting formation of a reversible resting state.

A plant immune receptor evolved recognition of caterpillar peptides through key molecular changes.

During neurotransmitter release, calcium-induced membrane insertion of the C2B domain of Synaptotagmin re-orients the bound SNARE complex which dilates the fusion pore in a mechanical lever action.

Using carefully controlled expression levels and a variety of optical pulse-chase assays in mammalian neurons, an updated model for the polarized transport of synaptic vesicle proteins, and the first steps of synaptic vesicle biogenesis, were uncovered.

The N-terminal domain (NTD) of the initiation factor eIF5 bound to the 40S subunit at the precise location vacated by eIF1 promotes tRNAi accommodation at AUG codons.

Allostery in an intrinsically disordered domain of glucocorticoid receptor is mediated by opposing thermodynamic signals that are directed through the production of different isoforms.

A 'hotspot' position in an olfactory receptor protein family underlies changes in odor tuning in different receptors at different times during evolution.