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Profiling spatially defined fibroblasts in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment identifies high levels of podoplanin and hypoxia in tumor-proximal fibroblasts associated with bad prognosis, whilst inflammatory markers define more distal fibroblast regions and associate with better outcomes.

Respiratory syncytial virus produces filamentous particles that change shape when the viral matrix detaches from the viral membrane, and this change in shape results in enhanced deposition of complement proteins, with potential downstream consequences.

Integration and segregation of information of memory and sensory in the hippocampus could be achieved by the coordination of distinct theta-gamma coding frameworks.

Osteoblast dedifferentiation and migration are injury responses that are differentially regulated and independent of regenerative bone formation.

Measurements of specialized metabolites across a population of 800 natural Arabidopsis thaliana accessions revealed different pressures and evolutionary processes that shaped their variation and distribution across Europe.

PIP₂ inhibits the proton-activated chloride (PAC) channel by selectively stabilizing its desensitized state.

Substrate releasing or inhibitor binding on the intracellular side of a glutamate transporter homologue require movements of the transport domain through the lipid membrane, which undergoes adaptive deformations.

Cryo-EM structures of Cys-loop receptor Alpo4 from the thermophilic worm Alvinella pompejana show that a sterol derivative CHAPS binds in and outside of its orthosteric binding site and induces a quaternary twist.

The development of Drosophila somatosensory neurons is spared under nutrient deficiency so that they grow more dendrites and make animals more sensitive to environmental stimuli.

Increased efficiency of targeted genome editing by simple addition of a bipartite-optimized tag at the N- and C-termini of effector proteins (Cas9 and cytosine-to-thymine base editor) is applicable in organismo and cell culture.