5,012 results found
    1. Epidemiology and Global Health

    A century of trends in adult human height

    NCD Risk Factor Collaboration (NCD-RisC)
    Height in early adulthood is an indicator that integrates across different dimensions of sustainable human development with links to health and longevity, nutrition, education and economic productivity.
    1. Epidemiology and Global Health
    2. Medicine

    Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission

    Lucy Rivett, Sushmita Sridhar ... Michael P Weekes
    3% of >1,000 asymptomatic healthcare workers in their workplace tested positive for SARS-CoV-2, suggesting that comprehensive screening programmes are vital to prevent acquisition of COVID-19 in hospitals.
    1. Epidemiology and Global Health
    2. Medicine

    Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

    Nick K Jones, Lucy Rivett ... Michael P Weekes
    Diminished incidence of COVID-19 amongst healthcare workers in a comprehensive screening programme demonstrates how effective infection control measures and staff testing can prevent hospitals becoming independent 'hubs' of SARS-CoV-2 transmission.
    1. Genetics and Genomics

    Association of genetic variation in COL11A1 with adolescent idiopathic scoliosis

    Hao Yu, Anas M Khanshour ... Carol A Wise
    Variation in type XI collagen alters estrogen-dependent signaling in the extracellular matrix and is identified as a genetic risk factor for adolescent idiopathic scoliosis, a common childhood deformity.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

    Geraldine M Clarke, Kirk Rockett ... MalariaGEN Consortium
    Increasing levels of glucose-6-phosphate dehydrogenase deficiency are associated with decreasing risk of cerebral malaria, but with increased risk of severe malarial anaemia.
    1. Biochemistry and Chemical Biology

    The dynamic conformational landscape of the protein methyltransferase SETD8

    Shi Chen, Rafal P Wiewiora ... Minkui Luo
    Integrated experimental-computational approaches were implemented to reveal the dynamic conformational landscape of a biologically relevant protein methyltransferase SETD8 for functional annotation.
    1. Genetics and Genomics
    2. Medicine

    Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

    Fernanda Morales Berstein, Daniel L McCartney ... Rebecca C Richmond
    GrimAge acceleration may increase the risk of colorectal cancer.
    1. Neuroscience

    Multimodal neural correlates of childhood psychopathology

    Jessica Royer, Valeria Kebets ... Boris C Bernhardt
    A multivariate approach identifying structural and functional factors underpinning dimensions of psychopathology in over 5000 children.
    1. Cancer Biology
    2. Epidemiology and Global Health

    Identifying metabolic features of colorectal cancer liability using Mendelian randomization

    Caroline Bull, Emma Hazelwood ... Emma E Vincent
    Increased genetic liability to colorectal cancer is associated with altered levels of circulating metabolites, including fatty acids, up to 40 years before average age of diagnosis.
    1. Developmental Biology
    2. Genetics and Genomics

    Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity

    Jason W Millington, George P Brownrigg ... Elizabeth J Rideout
    The ability to adjust body size in response to diet is greater in Drosophila females than males because of a sex difference in the nutrient-dependent regulation of the insulin pathway.

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