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Maternal CLAMP functions as a novel pioneer transcription factor to open chromatin and plays a targeted yet essential role in Drosophila zygotic genome activation.

Panproteome array analysis of antibody responses to a pneumococcal whole cell vaccine reveals consistent induction of immune responses to multiple surface proteins, despite individuals' unique pre-existing antibody profiles.

Cryo-EM structures of the eukaryotic clamp loader illustrate the large conformational changes that the clamp loader ATPase undergoes to open the circular sliding clamp and place it onto primer–template DNA.

Experimental and computational approaches reveal how ligand binding is coupled to voltage sensing in a HCN channels.

CNApp is a novel and unique web-based software that enables the performance of comprehensive and integrative analysis of genomic copy number alterations to uncover new associations with patient-oriented relevance.

Nuclei of the true slime mold Physarum polycephalum are continuously shuttled within the cytoplasmic flow across the gigantic syncytium, yet Physarum can establish and maintain gene expression heterogeneity between different structures of the organism.

Focusing on calcium oscillations in relation to neuronal morphology both in vitro and in vivo, rationally designed GCaMP-X provides a simple solution to neuronal toxicity of conventional GCaMP in imaging applications involving prolonged and/or strong expression of calcium probes.

β₃-AR signalling via cGMP in cardiomyocytes is regulated via phosphodiesterase 2 and 5 degradation, it is potentially cardioprotective, but dysregulated in heart failure through signal redistribution and higher phosphodiesterase activity.

The ubiquitous second messenger cyclic AMP, produced by Rv3645/MacE, controls long-chain fatty acid metabolism and intrinsic multidrug resistance in M. tuberculosis.

Poxin enzymes are a diverse family of insect and viral 2′3′-cGAMP nucleases, which evolved from self-cleaving RNA virus accessory proteases.