9,928 results found
    1. Structural Biology and Molecular Biophysics

    Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE

    Yao Li et al.
    A multidisciplinary platform featured by patient-derived RPEs is established to study the disease-causing mechanisms of BEST1 mutations, and demonstrates gene-supplemented rescue of the mutation-caused deficiency in Ca2+-dependent Cl- current in human RPE.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Patterns of within-host genetic diversity in SARS-CoV-2

    Gerry Tonkin-Hill et al.
    Characterisation of within-host diversity of SARS-CoV-2 provides insights into the mutational and selective mechanisms driving its evolution and has important implications for using within-host variation to inform transmission inference efforts.
    1. Structural Biology and Molecular Biophysics

    Calcium-driven regulation of voltage-sensing domains in BK channels

    Yenisleidy Lorenzo-Ceballos et al.
    Gating currents analysis at different Ca2+ concentrations of BK channels reveals a strong allosteric coupling between Ca2+- and voltage-sensing modules via equivalent contributions exerted by the RCK1 and RCK2 Ca2+-sites.
    1. Cell Biology

    Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans

    Chia-An Yen et al.
    Loss of FAD stemming from cell autonomous defects in mitochondrial proline catabolism impairs sperm quality male reproductive advantage in C. elegans.
    1. Epidemiology and Global Health
    2. Medicine

    Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

    Nick K Jones et al.
    Diminished incidence of COVID-19 amongst healthcare workers in a comprehensive screening programme demonstrates how effective infection control measures and staff testing can prevent hospitals becoming independent 'hubs' of SARS-CoV-2 transmission.
    1. Neuroscience

    Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression

    Edward Pym et al.
    Changes in Shank gene dosage alter voltage-activated calcium current and calcium-activated gene expression in a manner that parallels the effects of human Shank copy number variation on psychiatric disease risk.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The Ca2+-activated K+ current of human sperm is mediated by Slo3

    Christoph Brenker et al.
    The principal potassium ion channel in human sperm, Slo3, is primarily activated by calcium ions and controls the membrane potential of human sperm by intracellular calcium ion levels rather than intracellular pH.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons

    Pedro L Martinez-Espinosa et al.
    Sodium-activated potassium ion currents encoded by the kcnt1 gene delay action potential firing in DRG neurons by activity preceding an action potential.
    1. Neuroscience

    Current and future goals are represented in opposite patterns in object-selective cortex

    Anouk Mariette van Loon et al.
    Multivoxel pattern of fMRI data reveals how the brain distinguishes between relevant and irrelevant representations as representations adapt to the order in which they are required in multiple task sequences.
    1. Neuroscience

    Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states

    Kevin A Bolding et al.
    Intracortical circuits in mouse olfactory cortex stabilize odor-evoked activity patterns when upstream inputs, from olfactory bulb, become degraded under anesthesia.

Refine your results by:

Type
Research categories