6,075 results found
    1. Cancer Biology

    GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab

    Daiki Kato et al.
    The safety and strong antitumor effects of GPC1-specific CAR-T cells against GPC1-expressing solid tumors were demonstrated by using both syngeneic and xenogeneic mouse models.
    1. Cell Biology
    2. Immunology and Inflammation

    Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility

    Tobias X Dong et al.
    Orai1 channels activate intermittently in motile T cells, generating calcium transients, detected by a novel genetically encoded indicator and inducing pauses that favor antigen scanning.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin

    Cassandra L Stowe et al.
    Two cellular populations can be tracked in the same small animal model using near-infrared bioluminescence imaging, for the first time opening up the window for multi-coloured bioluminescence.
    1. Cell Biology
    2. Immunology and Inflammation

    T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse

    Tobias X Dong et al.
    Salsa6f is a novel, ratiometric genetically encoded Ca2+ indicator that combines the power of ratiometric chemical Ca2+ indicators with the ability, when expressed transgenically, to image cellular Ca2+ signals amid complex tissue environments in vivo.
    1. Immunology and Inflammation

    T cell immunodominance is dictated by the positively selecting self-peptide

    Wan-Lin Lo et al.
    The T cell repertoire can display immunodominance to an epitope as a result of optimal positive selection in the thymus by one self-peptide/MHC ligand.
    1. Cell Biology
    2. Immunology and Inflammation

    Identification of a super-functional Tfh-like subpopulation in murine lupus by pattern perception

    Stefanie Gryzik et al.
    A novel binning approach provides evidence for super-functional T cells with high activation potential and which exhibit Tfh-like functionalities and can help B cells.
    1. Immunology and Inflammation

    Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

    Marisa Stebegg et al.
    Older individuals have impaired conventional dendritic cell and T follicular helper cell formation upon vaccination, which can be rescued by treatment with a TLR7 agonist.
    1. Cancer Biology
    2. Computational and Systems Biology

    Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

    Jia-Ren Lin et al.
    t-CyCIF can be used to collect spatially-encoded, multiparametric data from fixed and embedded research or clinical specimens making it possible to probe the organization of tumors and tissues at a single-cell level.
    1. Immunology and Inflammation

    Gamma delta T cells recognize haptens and mount a hapten-specific response

    Xun Zeng et al.
    The T-cell receptors of gamma delta (γδ) T cells can recognize and trigger responses to small molecules and are thereby versatile drivers of immunity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture

    Tangsheng Yi, Jason G Cyster
    The receptor EBI2 is essential for correctly positioning CD4+ dendritic cells in the spleen so that they can present blood-borne antigens to T cells and thereby provoke an antibody response.

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