7,348 results found
  1. Point of View: Science, art, society and Klimt’s University of Vienna paintings

    Alberto E Pereda
    A set of paintings by Gustav Klimt highlights ongoing tensions in the relationships between art, science and society.
    1. Neuroscience

    Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure

    Aitak Farzi et al.
    CART exerts differential metabolic effects in response to activation of neurons of the Arc, where CART suppresses energy expenditure, while it enforces the reward characteristics of the LHA.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex

    Brian Bae et al.
    The crystal structure of Thermus transcription activation complexes containing the transcriptional activator CarD reveals a new mechanism for the activation of transcription.
    1. Cancer Biology

    GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab

    Daiki Kato et al.
    The safety and strong antitumor effects of GPC1-specific CAR-T cells against GPC1-expressing solid tumors were demonstrated by using both syngeneic and xenogeneic mouse models.
    1. Ecology
    2. Evolutionary Biology

    Brood care in a 100-million-year-old scale insect

    Bo Wang et al.
    The discovery of the earliest direct evidence of brood care in insects demonstrates a remarkably conserved egg-brooding reproductive strategy within scale insects in stasis for nearly 100 million years.
    1. Chromosomes and Gene Expression

    Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication

    Carl A Morrow et al.
    The discovery of a mechanism that causes DNA deletions during non-canonical DNA replication termination is described.
    1. Neuroscience

    Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior

    Takayuki Yamashita, Carl CH Petersen
    A learning-induced, motor-related, projection-specific signal from S1 to S2 accompanies reward-based-learning of a goal-directed sensorimotor transformation of whisker sensation into licking motor output.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis

    Cara C Boutte et al.
    Cell wall biosynthesis in mycobacteria is regulated by an unusual post-translational regulatory system that contributes to antibiotic tolerance during stress.
    1. Neuroscience

    Dissociable roles of the inferior longitudinal fasciculus and fornix in face and place perception

    Carl J Hodgetts et al.
    Structure-function associations in medial temporal lobe reflect specialised, behaviourally-relevant neurocognitive circuits for the perception of faces and places.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults

    William E Barry, Carl S Thummel
    Drosophila HNF4 directs a developmental switch at the onset of adulthood that suppresses diabetes by promoting mitochondrial function and supporting glucose-stimulated insulin secretion.

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