668 results found
    1. Microbiology and Infectious Disease

    CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release

    David O Ajasin et al.
    Effect of CCL2 on HIV-1 replication is mediated by mobilization of ALIX from F-actin leading to enhanced virion release and improved fitness and this requires the Gag late motif, LYPX.
    1. Cancer Biology
    2. Immunology and Inflammation

    CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

    Andrea Walens et al.
    CCL5-dependent macrophage recruitment drives breast cancer recurrence through collagen deposition in residual tumors.
    1. Cancer Biology
    2. Computational and Systems Biology

    Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

    Stephanie Berger et al.
    Six computationally designed and in vitro optimized protein inhibitors serve as molecular probes to reveal BCL2 profiles of different human cancers.
    1. Biochemistry and Chemical Biology

    Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

    Eva Plesch et al.
    Direct and selective activation of TRPML2 promotes macrophage migration through release of CCL2.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Essential yet limited role for CCR2+ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming

    Miriam Samstein et al.
    Inflammatory monocytes carry live Mycobacteria from the lung to draining lymph nodes and acquire many characteristics of dendritic cells but fail to stimulate proliferation of CD4 T cells.
    1. Biochemistry and Chemical Biology

    Cytokines: Revealing the secrets of secretion

    Antony Galione, Lianne C Davis
    An intracellular ion channel may have a central role in the release of cytokines by macrophages.
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation

    Yongjie Wei et al.
    Nutrient starvation activates autophagy by a novel signaling mechanism that is blocked by one of the major autophagy inhibitors.
    1. Microbiology and Infectious Disease

    Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members

    Elena Gonzalo-Gil et al.
    A subset of EC/VCs have CD4+T cells with resistance specific to R5-tropic HIV infection associated with transcriptional down-regulation of ccr5, a phenotype that appears to be heritable, across multiple generations.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma

    Ana R Grosso et al.
    Transcription beyond annotated gene boundaries expands the diversity of the cancer transcriptome with overexpressed oncogenes and RNA chimeras.
    1. Immunology and Inflammation

    High-endothelial cell-derived S1P regulates dendritic cell localization and vascular integrity in the lymph node

    Szandor Simmons et al.
    Impairment of the autocrine S1PR1-Gi signaling on HEVs results in high-endothelial cell apoptosis, reduced CCL21-secretion from HEVs, and cessation of HEV-DC interactions and lymphocyte immigration across the high-endothelial barrier.

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