584 results found
    1. Medicine
    2. Immunology and Inflammation

    Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade

    Hengqi Betty Zheng, Benjamin A. Doran ... Leslie S. Kean
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    An image-computable model of speeded decision-making

    Paul I Jaffe, Gustavo X Santiago-Reyes ... Russell A Poldrack
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Sleep spindle maturity promotes slow oscillation-spindle coupling across child and adolescent development

    Ann-Kathrin Joechner, Michael A Hahn ... Markus Werkle-Bergner
    Across four samples of children, adolescents, and young adults, age-related higher similarity of dominant, development-specific fast sleep spindles and adult-like fast sleep spindles is uniquely related to stronger and more precise slow oscillation-sleep spindle coupling.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma

    Alex W Chan, Malgorzata Broncel ... Sebastian Lourido
    Comprehensive characterization of kinase-dependent phosphorylation in the human pathogen Toxoplasma gondii identifies a trafficking adaptor complex required for virulence factor secretion and infection.
    1. Cancer Biology
    2. Immunology and Inflammation

    Cancer systems immunology

    Nathan E Reticker-Flynn, Edgar G Engleman
    Cancer systems immunology is a highly interdisciplinary field that is advancing our ability to understand and predict the complex behavior that orchestrates the interplay between tumors and the immune system.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Mutational sources of trans-regulatory variation affecting gene expression in Saccharomyces cerevisiae

    Fabien Duveau, Petra Vande Zande ... Patricia J Wittkopp
    Mapping mutations affecting gene expression within the yeast genome and within a gene regulatory network reveals properties of the raw material for regulatory variation.
    1. Immunology and Inflammation

    Overriding impaired FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in murine diabetic wound

    Ruchi Roy, Janet Zayas ... Sasha H Shafikhani
    Therapeutic potential of CCL3 for the treatment of diabetic foot ulcers if it is applied topically after the surgical debridement.
    1. Neuroscience

    Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing

    Aixin Zhang, Lei Jin ... Xiaoyin Chen
    Barcoded rabies virus tracing combined with single-cell RNAseq and in situ sequencing achieves high-throughput retrograde projection mapping and synaptic connectivity mapping at cellular resolution.
    1. Cancer Biology
    2. Computational and Systems Biology

    Comprehensive characterization of tumor microenvironment in colorectal cancer via molecular analysis

    Xiangkun Wu, Hong Yan ... Li Liang
    Integrated molecular analysis demonstrated that colorectal cancer can be classified into four molecular subtypes (proliferative, immunomodulatory, immunosuppressed, and immune-excluded subtypes), providing valuable insight into the intricate relationship between tumor microenvironment heterogeneity and various clinical phenotypes.
    1. Genetics and Genomics
    2. Neuroscience

    Transcriptional cartography integrates multiscale biology of the human cortex

    Konrad Wagstyl, Sophie Adler ... Armin Raznahan
    An atlas of cortical expression for 20,781 genes in the adult human brain, validated against multiscale datasets, from neuroimaging measures of structure and function to molecular cell and layer markers.

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