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    1. Neuroscience

    Interleukin-4 induces CD11c+ microglia leading to amelioration of neuropathic pain in mice

    Keita Kohno, Ryoji Shirasaka ... Makoto Tsuda
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Plant Biology

    Systems genomics of salinity stress response in rice

    Sonal Gupta, Simon C Groen ... Michael D Purugganan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Mesoscale functional architecture in medial posterior parietal cortex

    Riichiro Hira, Leah B Townsend ... Spencer LaVere Smith
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Stem Cells and Regenerative Medicine

    Il-6 signaling exacerbates hallmarks of chronic tendon disease by stimulating reparative fibroblasts

    Tino Stauber, Greta Moschini ... Jess G Snedeker
    IL-6 signaling drives fibroblast activation in tendinopathy, emerging as a promising therapeutic target for these increasingly prevalent and costly tendon conditions.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages

    Ainhoa Arbués, Sarah Schmidiger ... Damien Portevin
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Immunology and Inflammation

    Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions

    Sytse J Piersma, Shasha Li ... Wayne M Yokoyama
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cell Biology

    Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity

    Dan Wu, Venkateswararao Eeda ... Weidong Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathway

    Xin Ma, Meng Li ... Xinyan Han
    FMT alleviated the intestinal barrier damage caused by enterotoxigenic Escherichia coli infection in antibiotic-induced microbiome-disordered model through increasing the relative abundance of A. muciniphila in the intestine.
    1. Microbiology and Infectious Disease

    The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis

    Louise Tzung-Harn Hsieh, Belinda S Hall ... Rachel E Simmonds
    The secreted toxin mycolactone has severe effects on the cells lining blood vessels that will play a critical role in the development of swelling in Buruli ulcer disease.
    1. Cancer Biology

    Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab resistant HER2 positive breast cancer

    Yijia Hua, Ningjun Duan ... Yongmei Yin
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
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