238 results found
    1. Plant Biology

    The transcriptional regulator BZR1 mediates trade-off between plant innate immunity and growth

    Rosa Lozano-Durán, Alberto P Macho ... Cyril Zipfel
    The transcriptional regulator BZR1 acts as a molecular integrator of environmental cues regulating the trade-off between growth and innate immunity.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair

    Rose T Byrne, Audrey J Klingele ... Michael M Cox
    Experiments on E. coli show that multiple mechanisms contribute to extreme resistance to ionizing radiation in bacteria, with mutations to three genes for DNA repair having a prominent role in one evolved population.
    1. Cell Biology
    2. Immunology and Inflammation

    Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL

    Misty R Jenkins, Jane C Stinchcombe ... Gillian M Griffiths
    Inhibition of the catalytic activity of the Zap70 kinase reveals that discrete TCR-regulated events control the remodelling of the actin cytoskeleton when the cytotoxic T cell interacts with its target.
    1. Immunology and Inflammation

    Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

    Dorothy K Sojka, Beatrice Plougastel-Douglas ... Wayne M Yokoyama
    Natural killer cells that were commonly thought to circulate around the body can actually reside in distinct tissues, such as in the liver, skin or uterus, and do not re-circulate.
    1. Plant Biology

    Host-induced bacterial cell wall decomposition mediates pattern-triggered immunity in Arabidopsis

    Xiaokun Liu, Heini M Grabherr ... Andrea A Gust
    Arabidopsis lysozyme LYS1 generates soluble peptidoglycan fragments to mediate pattern-triggered immunity.
    1. Neuroscience

    Shared mushroom body circuits underlie visual and olfactory memories in Drosophila

    Katrin Vogt, Christopher Schnaitmann ... Hiromu Tanimoto
    One memory center in the fly brain processes distinct appetitive and aversive associative memories of olfactory and visual cues using shared local circuits.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus

    Paul G DeCaen, Yuka Takahashi ... David E Clapham
    Not all members of the bacteria sodium channel family are sodium channels - those found in Bacillus are highly adaptable and can be converted into many selectivity types.
    1. Plant Biology

    The kinase LYK5 is a major chitin receptor in Arabidopsis and forms a chitin-induced complex with related kinase CERK1

    Yangrong Cao, Yan Liang ... Gary Stacey
    The chitin-triggered immune response is mediated by a LYK5 and CERK1 receptor complex in Arabidopsis.
    1. Neuroscience

    Drep-2 is a novel synaptic protein important for learning and memory

    Till F M Andlauer, Sabrina Scholz-Kornehl ... Stephan J Sigrist
    Drep-2 is the first representative of the evolutionary conserved CIDE-N protein family found at synapses and is required for associative learning by functionally intersecting with metabotropic signaling.
    1. Neuroscience

    The neuronal architecture of the mushroom body provides a logic for associative learning

    Yoshinori Aso, Daisuke Hattori ... Gerald M Rubin
    A map of the entire array of cell types and potential projections in the mushroom body of the fruit fly brain provides insights into the circuitry that supports learning of stimulus-reward and stimulus–punishment associations.

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