The cancer-associated human ubiquitin ligase HUWE1 can adopt an auto-inhibited dimeric state, whose occupancy is regulated by competing intra- and intermolecular interactions of the dimerization region and by the tumor suppressor p14ARF.
A map of the entire array of cell types and potential projections in the mushroom body of the fruit fly brain provides insights into the circuitry that supports learning of stimulus-reward and stimulus–punishment associations.
Chandra M Khantwal, Sherwin J Abraham ... Merritt Maduke
The characterization of a previously unidentified “outward-facing open” conformational state provides a new framework for understanding the CLC transport mechanism.
Crystal structures of Nanos bound to Pumilio and target RNAs demonstrate how Nanos forms a molecular clamp to alter Pumilio RNA regulation and specificity in embryonic development and germline maintenance.
Guillem Torcal Garcia, Elisabeth Kowenz-Leutz ... Thomas Graf
A mutation in the lineage-determining regulator C/EBPα that increases the factor’s affinity for its partner PU.1 dramatically accelerates the velocity of B cell to macrophage transdifferentiation.
