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CD4 lineage commitment requires HDAC3 to prevent premature upregulation of CD8 lineage genes during T cell development.

Tissue-resident natural killer cells are important mediators of CD8 T responses in human cancers and these cells can be harnessed to increase immunity against pancreatic ductal adenocarcinoma.

Pathogen-specific CTLs are programmed to provide customized responses against infection, by inflammatory molecules that promote localization in peripheral and lymphoid tissues using alternative signaling mechanisms.

Insight into pre-existing SARS-CoV-2-specific T cell responses caused by heterologous T cell immunity directed against dissimilar epitopes, mediated by a public T cell receptor.

A fraction of human CD8⁺ T cells unequally partitions their lytic components during division, producing cells with heterogeneous killing capacities.

Multi-omic profiling of tumor-infiltrating T cells provides new insights into the differences in the effectiveness of CDK4 inhibitor between human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma patients.

Experiments in mice provide insights into the immunological mechanisms of action the vaccine adjuvant MF59.

Important nonlinear links between infection, inflammation, and disease severity were revealed using experimentally validated mathematical models.

Exercise can induce metabolic changes that strikingly impact cytotoxic T cell function and in turn affect cancer progression.

Naive CD4 and CD8 T cells in mice increase their survival capacity with age, but their numbers are not homeostatically regulated.