Emily N Truckenbrod, Kristina S Burrack ... Stephen C Jameson
Identification and characterization of the responses of T lymphocytes that are specific for 'self' tissue antigens, revealing the functional limits of immune tolerance.
Suhagi Shah, Gijsbert M Grotenbreg ... George S Yap
Proliferation and differentiation of CD8+ T cells into terminal effectors occurs in the marginal zone and red pulp, and is promoted by IL-12 through direct and indirect mechanisms.
The strength of TCR signalling determines the rate at which cells initiate a tightly coordinated signalling programme, without altering its organization.
Ngoc Lan Tran, Lorena Maria Ferreira ... Giovanni Sitia
Continuous perioperative IFNα therapy stimulates hepatic endothelial cells to build up physical vascular barrier that limits tumor cell entry into the liver and promotes long-term antitumor immunity.
Nicolas Loyer, Elizabeth KJ Hogg ... Jens Januschke
PAR-3/Baz function is regulated by CDK1 in asymmetrically dividing cells in the central and peripheral nervous system of Drosophila revealing direct regulation of cell polarity by the cell cycle machinery in the context of cell fate specification.
Michael A Kovacs, Maureen N Cowan ... Tajie H Harris
In the setting of CNS infection, meningeal lymphatic drainage promotes dendritic cell and T cell responses in the deep cervical lymph nodes but is not necessary for maintaining control of parasite in the brain.
Valentin Quiniou, Pierre Barennes ... David Klatzmann
The thymic selection of the human T-cell receptor repertoire releases polyspecific receptors with the ability to recognize and respond to peptides from unrelated viruses.
David G Saliba, Pablo F Céspedes-Donoso ... Michael L Dustin
TCR and CD40L microclusters are linked in synaptic ectosomes (extracellular vesicles) and released in the immunological synapse by helper T cells and induce dendritic cell maturation and cytokine production.
