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    1. Neuroscience

    Efficient sampling and noisy decisions

    Joseph A Heng et al.
    An efficient coding theory for higher-level cognitive processes reveals that humans efficiently adapt to contextual distributions by economizing on environmental prior information.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Identifying the immune interactions underlying HLA class I disease associations

    Bisrat J Debebe et al.
    HLA class I-disease associations have been studied for decades; a new approach for investigating the underlying mechanism can overcome past problems with interpretation and help to understand the etiology of human diseases.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Robust model-based analysis of single-particle tracking experiments with Spot-On

    Anders S Hansen et al.
    Spot-On is an easy-to-use website that makes a rigorous and bias-corrected modeling framework for analysis of single-molecule tracking experiments available to all.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity

    Margaret A Myers et al.
    Important nonlinear links between infection, inflammation, and disease severity were revealed using experimentally validated mathematical models.
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon et al.
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Microbiology and Infectious Disease
    2. Genetics and Genomics

    Dissection of the in vitro developmental program of Hammondia hammondi reveals a link between stress sensitivity and life cycle flexibility in Toxoplasma gondii

    Sarah L Sokol et al.
    A derived stress response trait may have contributed to the emergence of a globally dominant and promiscuous parasite.
    1. Immunology and Inflammation

    Ageing compromises mouse thymus function and remodels epithelial cell differentiation

    Jeanette Baran-Gale et al.
    Thymus ageing is characterised by both compositional and transcriptional shifts amongst epithelial cells that perturb their differentiation, contribute to organ atrophy and ultimately impair immune function.
    1. Structural Biology and Molecular Biophysics

    Sequence co-evolution gives 3D contacts and structures of protein complexes

    Thomas A Hopf et al.
    Interactions in protein complexes can be predicted from evolutionary information from genomic sequences.
    1. Evolutionary Biology

    Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species

    Tianming Wang et al.
    Identification and functional characterization of the first non-chordate kisspeptin neuropeptide system in the sea cucumber indicates the ancient origin of the intracellular signaling and physiological functions of this molecular system.
    1. Biochemistry and Chemical Biology

    Fatal amyloid formation in a patient’s antibody light chain is caused by a single point mutation

    Pamina Kazman et al.
    Identifying the patient-specific mutation that shifted the antibody light chain to the deadly fibrillar species provides new insight in the molecular pathogenesis of AL amyloidosis.