1,726 results found
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

    Emilia Dimitrova et al.
    The ZF-CxxC protein FBXL19 recruits kinase-associated Mediator to CpG islands of silent developmental genes in embryonic stem cells, which primes these genes for activation during differentiation and is required for embryonic development.
    1. Cell Biology

    CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets

    Jordina Guillén-Boixet et al.
    CPEB4's switch from translational repressor to activator is regulated during cell cycle by hyperphosphorylation of its intrinsically disordered domain, which controls its phase-separation into RNA-containing liquid-like droplets.
    1. Immunology and Inflammation
    2. Cell Biology

    Calcium-mediated shaping of naive CD4 T-cell phenotype and function

    Vincent Guichard et al.
    Calcium-calcineurin signaling cascade drives the acquisition of both the phenotype of the most self-reactive naive CD4 T cells and their enhanced cell-intrinsic ability to commit into induced regulatory T cells upon activation.
    1. Cell Biology

    Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation

    Hee Won Yang et al.
    Application of a live-cell reporter for CDK4/6 activity reveals rapid activity changes and reversibility in the cell-cycle entry signaling program.
    1. Cancer Biology
    2. Cell Biology

    The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells

    Shaheen Kabir et al.
    Targeting the CRL5 ubiquitin ligase complex in combination with CDK9 or MCL1 inhibition could combat innate and acquired resistance of cancer cells to MCL1-targeting therapeutics.
    1. Immunology and Inflammation

    A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model

    Yasunobu Arima et al.
    Pain sensation induces relapse in a mouse model of multiple sclerosis via a sensory-sympathetic signaling pathway.
    1. Cancer Biology

    Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases

    Paul A Clarke et al.
    Detailed molecular profiling investigations alongside antitumor testing and tolerability studies in animals suggest caution when considering the clinical development of inhibitors of CDK8 and CDK19, since a clear therapeutic window could not be demonstrated with two structurally distinct, potent and selective prototype drugs.
    1. Immunology and Inflammation

    Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells

    Alexandria C Wells et al.
    TCR-mediated downregulation of let-7 microRNAs licenses the differentiation of activated CD8 T cells into cytotoxic T lymphocytes.

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