A comprehensive structural, biochemical, and cell biological analysis reveals the molecular mechanism and significance of the conserved interaction of centromeric protein N (CENP-N) with the centromeric nucleosome.
Mutation of Glycine 34 to Arginine within the N-terminal tail of histone H3 alters post-translational modifications on Lysine 36 and is associated with a delay in replication restart, defective homologous recombination and an increase in genomic instability.
An integrative genome-wide approach supports a direct and collaborative role of ETS and AP-1 transcription factors in maintaining endothelial cell-specific and anti-inflammatory gene expression programs.
A genetic analysis has identified the cholinergic SIA sublateral motor neurons, which innervate all four body wall muscles separately, as crucial regulators of turning around during sleep in Caenorhabditis elegans.
Transcription factors that specify the identity of individual neuron types via activating terminal differentiation gene batteries also restrict cellular plasticity via altering the chromatin landscape.