A biophysical model in which kinetochore microtubules nucleate at kinetochores and growth polward along nematic streamlines quantitatively explains kinetochore microtubule lengths, orientations, and spatially varying dynamics in metaphase human spindles.

Set1 has roles in chromatin organization and transcriptome control that are largely independent of histone H3 lysine 4 methylation.

The role of LIS1 in dynein-mediated transport in various biological contexts is reviewed with a focus on recent studies that revealed a new mechanism by which LIS1 functions.

A structural model of the dynamic complex comprising the histone reader RNF169 bound to an ubiquitylated nucleosome core particle reveals a three-pronged binding mechanism, which provides specificity for the recognition of DNA double-strand break sites.

Human cells center the position of the metaphase plate before anaphase onset to ensure the formation of equal-sized daughter cells.

The histone modification H3K9me2 marks peripheral heterochromatin and ensures positional information is safeguarded through cell division such that individual lamina-associated domains are re-established at the nuclear periphery in daughter nuclei.

Chromosomal instability of cancer can be quantitatively measured by phylogenetic analysis of 200 tumor cells while using evolutionary principles to account for cellular selection.