236 results found
    1. Structural Biology and Molecular Biophysics

    A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl/H+ transport cycle

    Tanmay S Chavan et al.
    Crystallography together with electron-resonance spectroscopy, molecular-dynamics simulations, and transport measurements reveal the molecular details of protein conformational change, and how this change contributes to function in a CLC-type chloride/proton exchanger.
    1. Developmental Biology
    2. Immunology and Inflammation

    Linker histone H1.2 and H1.4 affect the neutrophil lineage determination

    Gabriel Sollberger et al.
    Linker histones affect the lineage determination of granulocyte precursor cells via regulation of the transcription factor GATA-2.
    1. Microbiology and Infectious Disease

    Essential function of the alveolin network in the subpellicular microtubules and conoid assembly in Toxoplasma gondii

    Nicolò Tosetti et al.
    A combination of high-resolution microscopy and reverse genetics identified key components of the alveolin network playing an essential role in the assembly of subpellicular microtubules and conoid in Toxoplasma gondii..
    1. Neuroscience

    Wireless recording from unrestrained monkeys reveals motor goal encoding beyond immediate reach in frontoparietal cortex

    Michael Berger et al.
    The novel Reach Cage allows neurophysiology studies of structured behavior with unrestrained Rhesus macaques showing that the frontoparietal reach network is selective for reach goals outside the immediately reachable space.
    1. Developmental Biology
    2. Neuroscience

    Caenorhabditis elegans processes sensory information to choose between freeloading and self-defense strategies

    Jodie A Schiffer et al.
    C. elegans nematodes use a sensory-neuronal circuit to determine whether to defend themselves from hydrogen peroxide attack or to freeload off orthologous protective defenses from bacteria in their surrounding environment.
    1. Chromosomes and Gene Expression

    Centromere deletion in Cryptococcus deuterogattii leads to neocentromere formation and chromosome fusions

    Klaas Schotanus, Joseph Heitman
    Centromere deletion in Cryptococcus deuterogattii results in neocentromeres, which span actively expressed genes and at elevated temperatures cen10∆ mutants are unstable leading to chromosome fusion and silencing of the neocentromere.
    1. Immunology and Inflammation

    Reversible promoter methylation determines fluctuating expression of acute phase proteins

    Shi-Chao Zhang et al.
    DNA methylation status can be exploited to finely and reversibly tune the expression of highly inducible genes with CpG-poor promoters in response to environmental cues.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure

    Andrea Ruiz-Velasco et al.
    Targeting mir128-3p could prevent cardiac insulin resistance in the non-infarcted myocardium and limit cardiac injury after myocardial infarction, delaying the development of heart failure.
    1. Physics of Living Systems

    Stochastic yield catastrophes and robustness in self-assembly

    Florian M Gartner et al.
    Fluctuations in the availability of particles for binding can completely jeopardize yield in heterogeneous self-assembly.
    1. Stem Cells and Regenerative Medicine

    Derivation of trophoblast stem cells from naïve human pluripotent stem cells

    Chen Dong et al.
    Naive hPSCs can readily give rise to human trophoblast stem cells, thus demonstrating their extraembryonic lineage potential and providing a new model system to study human trophectoderm specification.

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