96 results found
    1. Microbiology and Infectious Disease

    Functional insights from a surface antigen mRNA-bound proteome

    Larissa Melo do Nascimento et al.
    A robust procedure to purify mRNAs and their associated proteins identify CFB2 as the critical protein that binds and influences the fate of the main virulence factor in Trypanosoma brucei.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks

    Bryan A Leland et al.
    A single-cell assay reveals that the genetic rewiring that underlies PARP inhibitor resistance drives altered DNA double-strand break end resection pathway choice.
    1. Developmental Biology

    Pregnancy success in mice requires appropriate cannabinoid receptor signaling for primary decidua formation

    Yingju Li et al.
    Cannabinoid signaling is critical for integration of vascular system and uterine decidualization.
    1. Developmental Biology
    2. Genetics and Genomics

    Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

    Ryan J Geusz et al.
    Analysis of epigenome maps from human pancreatic progenitors and functional validation in zebrafish identify LAMA1 and CRB2 as type 2 diabetes risk-associated genes with roles in pancreatic development.
    1. Developmental Biology
    2. Plant Biology

    Genetic analysis of the Arabidopsis TIR1/AFB auxin receptors reveals both overlapping and specialized functions

    Michael J Prigge et al.
    Genetic analyses reveal that the TIR1/AFB auxin receptors have broadly overlapping functions throughout plant development, but that the AFB1 receptor has a specialized role in a rapid auxin response.
    1. Computational and Systems Biology

    Inference of gene regulation functions from dynamic transcriptome data

    Patrick Hillenbrand et al.
    Quantitative analysis of time-dependent transcription data elucidates the signal processing within the genetic network that regulates transcriptional cell cycle oscillations in yeast.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity

    Nairita Maitra et al.
    Extensive molecular profiling shows how loss of highly similar, paralogous ribosomal proteins lead to distinct phenotypic outputs, through translational control of specific mRNAs.
    1. Cell Biology
    2. Developmental Biology

    Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation

    Jennifer Winstanley et al.
    The in vivo activity of Tolloid during Drosophila dorsal-ventral patterning is regulated by the differential specificity of its non-catalytic domains in mediating substrate and Collagen IV interaction.
    1. Cell Biology

    Cross-compartment signal propagation in the mitotic exit network

    Xiaoxue Zhou et al.
    The mitotic exit network signals from spindle pole bodies to the nucleolus through the dynamic localization of its terminal kinase complex Dbf2-Mob1.
    1. Neuroscience

    TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro

    Hugo Balleza-Tapia et al.
    TrpV1 receptor activation rescues cognition-relevant network dynamics in mouse hippocampus in an acute Alzheimer disease model providing a novel therapeutic target.

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