7,713 results found
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Histone H1 prevents non-CG methylation-mediated small RNA biogenesis in Arabidopsis heterochromatin

    Jaemyung Choi, David B Lyons, Daniel Zilberman
    Linker histone H1 and cytosine DNA methylation in contexts other than CG explain patterns of 24 nucleotide small RNA biogenesis in Arabidopsis thaliana.
    1. Cancer Biology
    2. Genetics and Genomics

    Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization

    Van Thien Chi Nguyen, Trong Hieu Nguyen ... Le Son Tran
    SPOT-MAS (screening for the presence of tumor by methylation and size) is an affordable and effective multi-cancer early detection test analyzing multiple features of circulating tumor DNA.
    1. Plant Biology

    Regulation of rice root development by a retrotransposon acting as a microRNA sponge

    Jungnam Cho, Jerzy Paszkowski
    Retrotransposon-derived messenger RNA plays a critical role in rice root development via sequestration of miR171, which suggests a novel trans-acting regulation by transposable elements.
    1. Evolutionary Biology

    Microstructural and crystallographic evolution of palaeognath (Aves) eggshells

    Seung Choi, Mark E Hauber ... David J Varricchio
    The eggshells of palaeognath birds (e.g. ostrich, moa, kiwi, emu) have diverse homology and convergent features, and are useful modern analogues for the evolution of non-avian dinosaur eggshells.
    1. Neuroscience

    Novel cyclic homogeneous oscillation detection method for high accuracy and specific characterization of neural dynamics

    Hohyun Cho, Markus Adamek ... Peter Brunner
    Detecting neural oscillations in time and frequency domains enables the detailed study of spatiotemporal dynamics of oscillations throughout the brain and the investigation of biomarkers that index functional brain areas.
    1. Cancer Biology

    Siglec1-expressing subcapsular sinus macrophages provide soil for melanoma lymph node metastasis

    Rohit Singh, Beom K Choi
    When pioneer metastatic cells enter a sentinel lymph node through afferent lymphatics subcapsular sinus, macrophages provide them soil to proliferate and colonize lymph node.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3

    Ho-Ryun Chung, Chao Xu ... Sarah Kinkley
    PHF13 interacts with transcriptional complexes containing RNA polymerase II to recruit/stabilize them at H3K4me2/3 containing active or bivalent promoters.
    1. Microbiology and Infectious Disease

    The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector

    Xiaotian Tang, Yongguo Cao ... Erol Fikrig
    A new tick metabolic pathway that is connected to the survival of the Lyme disease spirochete was identified, which may lead to new ways to interfere with the spirochete life cycle.
    1. Cell Biology

    LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation

    Chan Hee J Choi, William Barr ... Paul Cohen
    Profiling the adipocyte secretome reveals LRG1 as a novel adipokine that promotes insulin sensitivity and modulates inflammation triggered by release of cytochrome c from dead/dying cells, describing a new pathway at the intersection of obesity and its systemic sequelae.
    1. Developmental Biology

    Histone deacetylase 1 maintains lineage integrity through histone acetylome refinement during early embryogenesis

    Jeff Jiajing Zhou, Jin Sun Cho ... Ken WY Cho
    Histone deacetylase 1 (Hdac1) plays a crucial role in maintaining differential histone acetylation states of enhancers in various germ layers and regulates the transcriptional program both temporally and spatially.

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