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Integrative structural biology reveals a novel complex comprising the TATA-box-binding protein, TBP, and two subunits, TAF11 and TAF13, of General Transcription Factor TFIID, suggesting a new regulatory state in TFIID function in RNA polymerase II transcription initiation.

Combined tissue clearing, 3D-immunofluorescence, and electron tomography spatially revealed the dynamics of early HIV-1 spread within lymphoid tissues of humanized mice at the resolution of single cells and individual virions.

Structural neuroimaging of 40,087 individuals identifies a distinct brain morphological profile associated with metabolic syndrome, linking cardiometabolic risk to cognitive performance, microscale tissue composition, and macroscale brain network architecture.

RNA chaperone Hfq dynamically binds various pools of cellular RNAs to execute different regulatory functions.

White matter microstructure in hemianopia patients indicates that blindsight requires an intact connection between the lateral geniculate nucleus and extrastriate cortex.

The bee gut microbiota contributes to the metabolism of the cyanogenic glycoside amygdalin.

Signal-peptide cleavage of HIV-1 envelope glycoprotein is delayed because of alpha-helical structure covering the cleavage site, effecting early cleavage alters the folding pathway and resulting in localized misfolding and reduced viral fitness.

MorphoGraphX summarizes full 3D datasets as curved surface images (2.5D), enabling the efficient quantification of growth and gene expression data from large time-lapse volumetric datasets.

The infection of T helper lymphocytes by SARS-CoV-2, mediated via the CD4 molecule, alters cellular function and enhances expression of the anti-inflammatory cytokine IL-10, potentially impairing immune response in individuals with COVID-19.

Synaptic modulations alone imbue networks with computational capabilities comparable to recurrent connections on several neuroscience-relevant tasks, which manifest in fundamentally different neuronal dynamics.