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    1. Computational and Systems Biology

    Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies

    Wen Yan, Saad Ansari ... Michael Shelley
    aLENS implements new parallel methods to resolve cytoskeletal assembly dynamics with high stability, physical consistency, and scalability.
    1. Developmental Biology
    2. Neuroscience

    Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

    Subhash Kulkarni, Monalee Saha ... Pankaj Jay Pasricha
    Mesoderm-derived enteric neurons born in the post-natal vertebrates drive maturation and aging of the enteric nervous system.
    1. Neuroscience

    The integrated brain network that controls respiration

    Friedrich Krohn, Manuele Novello ... Laurens WJ Bosman
    The primary rhythm generators controlling respiration are integrated in a much larger network of brain regions, including areas not typically considered to be respiratory control centers, and that allow respiration to be adapted to all forms of ongoing behavior.
    1. Neuroscience

    Emergence of transformation-tolerant representations of visual objects in rat lateral extrastriate cortex

    Sina Tafazoli, Houman Safaai ... Davide Zoccolan
    Neuronal recordings from rat visual cortex reveal an object-processing pathway, along which neuronal representations become increasingly capable of supporting recognition of visual objects in spite of variation in their appearance.
    1. Cell Biology

    Surface curvature and basal hydraulic stress induce spatial bias in cell extrusion

    Cheng-Kuang Huang, Xianbin Yong ... Chwee Teck Lim
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

    Kangcheng Song, Miao Wei ... Lei Chen
    The binding sites of two distinct TRPC5 inhibitors clemizole and HC-070 are revealed by cryo-EM.
    1. Structural Biology and Molecular Biophysics

    Dissecting Mechanisms of Ligand Binding and Conformational Changes in the Glutamine-Binding Protein

    Zhongying Han, Sabrina Panhans ... Thorben Cordes
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Inhibition of mitochondrial protein import and proteostasis by a pro-apoptotic lipid

    Josep Fita-Torró, José Luis Garrido-Huarte ... Markus Proft
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator

    Adrian L Sanborn, Benjamin T Yeh ... Roger D Kornberg
    Transcriptional activation domains achieve rapid, dynamic, specific interaction with Mediator through binding of an unstructured peptide to multiple hydrophobic surfaces without particular amino acid side chain interactions.
    1. Developmental Biology
    2. Genetics and Genomics

    Feedback between a retinoid-related nuclear receptor and the let-7 microRNAs controls the pace and number of molting cycles in C. elegans

    Ruhi Patel, Himani Galagali ... Alison R Frand
    A genetic oscillator composed of NHR-23 and let-7 family of microRNAs links the molting cycle timer and the heterochronic pathway to regulate the pace of molting in C. elegans and ensure that worms molt only four times.