The METHYL-CpG-BINDING DOMAIN 7 (MBD7) complex promotes the activation (rather than repression) of transgenes that undergo DNA methylation and it does so without significantly altering their methylation status, placing this complex downstream of DNA methylation.
Sandipan Dasgupta, Daniella Y Dayagi ... Jeffrey E Gerst
The RNA transferome comprises full-length mRNAs and lncRNAs that undergo non-selective and expression-dependent transfer between mammalian cells in culture via actin-based tunneling nanotubes.
Definition of leukemia gene expression mechanisms reveals general principles of cancer gene control and offers a pharmacologic strategy for its therapeutic reprogramming.
William F Richter, Rohan N Shah, Alexander J Ruthenburg
FLT3-ITD/STAT5A signaling is more sensitive to Dot1L inhibition than the canonical MLL-fusion activated drivers of leukemogenesis, providing a potential therapeutic avenue for one of the most frequent lesions in leukemia.
The C terminal fusion partners of TAZ-CAMTA1, YAP-TFE3 and potentially other TAZ/YAP fusion proteins in cancer recruit epigenetic modifiers that modulate a baseline TEAD-based transcriptional program.
In the model plant Arabidopsis thaliana genome dynamic exchanges of histone variants control the organization of histone modifications into chromatin states, acting as molecular landmarks.
