Comprehensive genomic and population genetic analyses of a non-recombining chromosome in white-throated sparrows reveal the actions of purifying selection, positive selection, and balancing selection, expanding our understanding of supergene evolution.

FMNL1β is phosphorylated on S1086 in a protein kinase C δ (PKCδ)-dependent manner and S1086-phosphorylated FMNL1β acts downstream of PKCδ to regulate centrosome and multivesicular bodies polarization to the immunological synapse and exosome release.

Microtubule-depolymerizing kinesin, Klp10A, prevents overgrowth of the mother centrosome to prevent undesirable asymmetries during asymmetric divisions of Drosophila male germline stem cells.

Generation and validation of a new mouse strain as a tool to demonstrate the implication of p38γ/p38δ in inflammation through the regulation of the transcription factor MEF2D’s activity.

In silico modeling identify allosteric CXCR4 modulators that block receptor nanoclustering and chemoattractant sensing without affecting other CXCL12-mediated functions, and reduce tumorigenesis and metastasis in a zebrafish model.

ICAM-1 engagement controls hepatic cell polarity, but this receptor can also signal without prior leukocyte interaction, thanks to its confinement into apical, microvilli-enriched, bile-canalicular domains and its actin connector EBP50.

Light signaling components interact with a histone H2B deubiquitination module, adjusting chromatin states at global level during Arabidopsis seedling development.

Cryo-EM reveals the regulation of RUVBL1 and RUVBL2 AAA-ATPases by DHX34, a helicase involved in nonsense-mediated mRNA decay (NMD), and suggests mechanisms for how RUVBL1 and RUVBL2 function in NMD.

The ability of calcium waves to exert different effects on calcineurin activity depending on subcellular location is mediated by the distribution of calmodulin.

Structural network topology develops during adolescence to facilitate activation of the fronto-parietal executive system with lower theoretical energetic cost.