12 results found
    1. Evolutionary Biology
    2. Neuroscience

    CNGA3 acts as a cold sensor in hypothalamic neurons

    Viktor V Feketa et al.
    CNGA3 is a cold-potentiated ion channel that confers cold sensitivity to mouse hypothalamic neurons, whereas CNGA3 from hibernating ground squirrels is cold-insensitive.
    1. Neuroscience

    The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision

    Frans Vinberg et al.
    Molecular, genetic, and functional analysis is used to show that the olfactory Na+/Ca2+, K+ exchanger NCKX4 is expressed in cone photoreceptors and is critical for the wide operating range and high temporal resolution of cone-mediated vision.
    1. Developmental Biology
    2. Neuroscience

    The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli

    Nobuko Inoue et al.
    The critical period in the mouse olfactory system is defined by activity-dependent synapse formation induced by Semaphorin7A/PlexinC1 signaling in the neonatal glomeruli.
    1. Cell Biology
    2. Neuroscience

    Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice

    Ruchira Sharma et al.
    G protein-coupled odorant receptors regulate their own gene transcription based on their cell surface trafficking, which is facilitated by receptor transporting protein (RTP) family members.
    1. Developmental Biology
    2. Neuroscience

    The role of the NMD factor UPF3B in olfactory sensory neurons

    Kun Tan et al.
    The nonsense-mediated RNA decay (NMD) branch-specific factor UPF3B influences olfactory sensory neuron cell populations, the olfactory receptor repertoire, and antimicrobial gene expression.
    1. Genetics and Genomics
    2. Neuroscience

    Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated

    Ximena Ibarra-Soria et al.
    The neuronal composition of a mouse’s nose is individually unique due to a combination of olfactory experience and genetic variation local to olfactory receptor genes.
    1. Neuroscience

    Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket

    Wendy Wing Sze Yue et al.
    Visual pigments with a longer peak-absorption wavelength or an open chromophore-binding pocket are generally noisier, being more prone to spontaneous activity.
    1. Cell Biology

    Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

    Jan N Hansen et al.
    Trafficking of optogenetic tools to primary cilia using nanobodies allows to study cAMP signaling with spatial and temporal resolution independent of the cell body.
    1. Neuroscience

    The activity-dependent histone variant H2BE modulates the life span of olfactory neurons

    Stephen W Santoro, Catherine Dulac
    A genome-organizing protein that is present only in the olfactory system of mice has been found to orchestrate changes in the relative numbers of different odor-sensing neurons on the basis of how active these neurons are.
    1. Neuroscience

    A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction

    William Thomas Keenan et al.
    A single class of neurons switches both its sensory detection and neurotransmission mechanisms to support transient or sustained physiological output.

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