3,544 results found
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Molecular basis for the adaptive evolution of environment-sensing by H-NS proteins

    Xiaochuan Zhao et al.
    Combining in silico and experimental approaches to identify and understand the residue changes in the H-NS protein that allowed bacteria to adapt environment-sensing to different habitats.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells

    Paula Freire-Pritchett et al.
    Promoter interactome maps in human embryonic stem cells (ESCs) and ESC-derived early neuroectodermal progenitors link distal enhancers to putative target genes, reveal lineage-specific cis-regulatory architecture and shed light on the logic of gene regulation by multiple enhancers.
    1. Structural Biology and Molecular Biophysics

    Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas

    Alison B Hickman et al.
    The tetrameric structure of a casposase bound to DNA and its biochemical properties show how a transposase could have evolved to perform CRISPR-Cas spacer acquisition.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Cis-regulatory basis of sister cell type divergence in the vertebrate retina

    Daniel P Murphy et al.
    While photoreceptor and bipolar cells exhibit very similar cis-regulatory grammars, subtle differences in homeodomain motif enrichment represent a key distinction driving the divergence in their transcriptomes.
    1. Cell Biology
    2. Genetics and Genomics

    Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome

    Martin Wegner et al.
    Cloning-free 3Cs technology is developed for the generation of sequence-bias-free covalently closed circular synthesized (3Cs) CRISPR/Cas gRNA libraries that can interrogate the coding and noncoding human genome.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Predominance of cis-regulatory changes in parallel expression divergence of sticklebacks

    Jukka-Pekka Verta, Felicity C Jones
    Cis-regulation such as enhancers and promoters plays a major role in parallel gene expression divergence and has features that make it a well-poised substrate for adaptive evolution.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Mechanism of environmentally driven conformational changes that modulate H-NS DNA-bridging activity

    Ramon A van der Valk et al.
    The DNA-bridging efficiency of H-NS, a genome organising and transcription regulatory protein, is modulated by changes in environmental conditions of the cell, which drive a structural rearrangement of the protein.
    1. Genetics and Genomics
    2. Plant Biology

    The Arabidopsis active demethylase ROS1 cis-regulates defence genes by erasing DNA methylation at promoter-regulatory regions

    Thierry Halter et al.
    Active DNA demethylation at some defence gene promoters is causal for DNA binding of WRKY transcription factors as well as for transcriptional activation of these genes during plant immune response.
    1. Microbiology and Infectious Disease

    The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis

    Anat Melamed et al.
    The human leukemia virus HTLV-1 causes abnormal chromatin looping in tens of thousands of infected T cell clones in each host, and abnormal host transcription both flanking the integrated provirus and at distant loci in cis.
    1. Developmental Biology
    2. Neuroscience

    Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors

    Michael S Fleming et al.
    Cis and trans activation of the receptor tyrosine kinase RET lead to similar biological outcomes in rapidly adapting mechanoreceptors in vivo.

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