5,650 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans

    Teresa Wei-sy Lee et al.
    The transgenerational inheritance of lifespan is facilitated by the accumulation of repressive chromatin across generations.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Histone Methylation: Navigating the structure of COMPASS

    Karolin Luger, Jonathan W Markert
    Cryo-electron microscopy reveals how ubiquitination promotes the methylation of histone H3 by the histone-modifying complex COMPASS.
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    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome

    Evan J Worden et al.
    The structure of the COMPASS methyltransferase bound to an H2B-ubiquitinated nucleosome provides insights into mechanisms of trans-histone cross-talk and the dynamic role of H2B ubiquitination in stimulating histone methylation.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Efficient support of virus-like particle assembly by the HIV-1 packaging signal

    Mauricio Comas-Garcia et al.
    The packaging signal in HIV-1 genomic RNA supports in vitro particle assembly more efficiently than control RNAs, probably explaining its selective packaging during virus assembly in vivo.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Dissection of specific binding of HIV-1 Gag to the 'packaging signal' in viral RNA

    Mauricio Comas-Garcia et al.
    While HIV-1 Gag protein binds tightly to several RNAs, it binds to the viral RNA 'packaging signal' with higher specificity than to control RNAs.
    1. Neuroscience

    Magnetosensation: Finding a worm's internal compass

    Catharine H Rankin, Conny H Lin
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    1. Structural Biology and Molecular Biophysics

    Myosin motors fragment and compact membrane-bound actin filaments

    Sven K Vogel et al.
    A combination of single-molecule imaging and an in vitro model of the cell cortex has allowed the interactions between actin filaments and filaments made of myosin II to be studied in detail.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory

    Agustina D'Urso et al.
    Epigenetic transcriptional memory employs a novel regulatory strategy to create a heritable poised state by remodeling and repurposing complexes involved in active transcription.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Auxiliary subunits keep AMPA receptors compact during activation and desensitization

    Jelena Baranovic, Andrew JR Plested
    The auxiliary protein Stargazin limits the conformational dynamics of AMPA-type glutamate receptors in cell membranes, as revealed by 'molecular rulers' deployed on the seconds to milliseconds timescale.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

    Max A Horlbeck et al.
    Integrated modeling of sgRNA positioning, chromatin accessibility, and sequence features enables accurate prediction of effective target sites for CRISPR-mediated transcriptional modulation and design of highly active libraries for genome-scale genetic screens.

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