3,286 results found
    1. Cell Biology

    Autophagy: COPII vesicles and the expansion of the phagophore

    Catherine Rabouille
    A new study has identified the proteins that adapt COPII vesicles to the needs of starving cells.
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    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments

    Svetlana O Dodonova et al.
    A molecular model of the assembled COPI coat, determined by cryo-electron tomography of an in vitro reconstituted budding reaction, reveals details of interactions mediating coat assembly and shows the binding site of ArfGAP2.
    1. Cell Biology

    COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal

    Peng Xu et al.
    COPI vesicle coat protein recognizes a ubiquitin sorting signal on an exocytic v-SNARE to mediate recycling.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment

    Liang Ge et al.
    Building on previous work (Ge et al., 2013), it is shown that the ER-Golgi intermediate compartment is a platform for the production of COPII vesicles as precursor membranes for the lipidation of LC3, which is an essential step in autophagosome biogenesis.
    1. Computational and Systems Biology

    A network of epigenetic modifiers and DNA repair genes controls tissue-specific copy number alteration preference

    Dina Cramer et al.
    The genetic background of a cancer cell and the chromatin organization of the tissue-of-origin impact the amount, length and position of somatic copy number alterations in cancer.
    1. Cancer Biology

    Systematic identification of mutations and copy number alterations associated with cancer patient prognosis

    Joan C Smith, Jason M Sheltzer
    Gene copy number provides more prognostic information than gene mutation status in cancer.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Independent amylase gene copy number bursts correlate with dietary preferences in mammals

    Petar Pajic et al.
    Comprehensive analyses of amylase duplications and salivary activity across mammals underscore the importance of recurrent copy number variation as a flexible and rapid evolutionary mechanism.
    1. Cancer Biology
    2. Human Biology and Medicine

    Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

    Brenton R Paolella et al.
    Partial copy loss of spliceosome genes are common non-driver gene dependencies in cancer.
    1. Cancer Biology
    2. Human Biology and Medicine

    Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death

    Haley Hieronymus et al.
    The percentage of a tumor’s genome with alterations in copy number is correlated with increased mortality across a range of tumor types and can be measured using a clinically approved sequencing assay.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The structure of the COPI coat determined within the cell

    Yury S Bykov et al.
    Cryo-electron tomography of COPI vesicles in the Golgi reveals coat structure, disassembly dynamics, cargo binding, and morphological variability.

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