Smad and Schnurri transcription factors engage in context-dependent interactions as well as independent genomic activities, leading to regulation of collagen secretion to mediate body size regulation in C. elegans.
Georgia Maria Sagia, Xenia Georgiou ... Sofia Dimou
Unconventional secretion of a plasma membrane purine transporter via Golgi-bypass is established at an early ER-associated secretory compartment revealing that specific cargoes define alternative trafficking routes.
Calreticulin, beyond its known role as a chaperone, also serves as an endoplasmic reticulum repressor of ATF6⍺, selectively regulating one arm of the unfolded protein response.
Spatiotemporal mapping of a variety of proteins in and around the Golgi apparatus in budding yeast was performed using super-resolution live imaging microscopy and identified the ER-Golgi intermediate compartment that matures into the Golgi.
TGN46 is a cargo receptor, with its luminal domain being necessary and sufficient to load soluble secretory proteins into transport carriers for export out of the trans-Golgi network.
There was substantial change in primary care activity following the onset of the COVID-19 pandemic in March 2019 as indicated by key measures reflective of clinical activity in general practice but service was largely restored by April 2021.
The yeast syntaxin homolog Tlg2p-residing sub-compartment within the trans-Golgi network is the primary endocytic-accepting region that serves as an early/sorting compartment.
